School of Plant Protection, Anhui Agricultural University, Hefei, Anhui Province 230036, China; Provincial Key Laboratory for Agri-Food Safety, Anhui Province 230036, China.
Provincial Key Laboratory for Agri-Food Safety, Anhui Province 230036, China.
J Hazard Mater. 2019 Mar 5;365:857-867. doi: 10.1016/j.jhazmat.2018.11.075. Epub 2018 Nov 20.
The safety of Traditional Chinese Medicine (TCM) is of concern worldwide. Herein, Paeoniae Radix Alba, Chaenomelis Fructus and Moutan Cortex, representing three medicinal components, were subjected to toxicological analysis to investigate possible pesticide contamination. Exposure using a point estimate model identified 47 residues that were simultaneously validated by the QuEChERS-UPLC-MS/MS method, which is sufficiently reliable for measuring residue concentrations. Of the 313 samples tested, 94.57% contained pesticide residues, with concentrations ranging from 0.10 to 1199.84 μg kg, of which >83.17% contained 4-15 different residues. Carbendazim was the most frequently detected pesticide (>85%), and procymidone, pendimethalin and phoxim were also abundant (median concentration = 15.33-623.12 μg kg). Risk assessment based on the hazard quotient/hazard index (HQ/HI) approach revealed that exposure to pesticide residues in all three TCMs (95th percentile) were far below levels that might pose a health risk. However, insecticides contributed to cumulative exposure, especially phoxim, and worryingly, several banned pesticides were detected. The results are of theoretical and practical value for evaluating the safety TCMs, and could improve their quality and safety.
中药（TCM）的安全性受到全球关注。在此，白芍、木瓜和丹皮作为三种药用成分，进行了毒理学分析，以调查可能的农药污染。采用点估计模型进行暴露评估，确定了 47 种同时被 QuEChERS-UPLC-MS/MS 方法验证的残留，该方法足以准确测量残留浓度。在测试的 313 个样本中，94.57%含有农药残留，浓度范围为 0.10-1199.84μg/kg，其中>83.17%含有 4-15 种不同的残留。多菌灵是最常检测到的农药（>85%），其次是百菌清、甲草胺和辛硫磷（中位数浓度=15.33-623.12μg/kg）。基于危害系数/危害指数（HQ/HI）方法的风险评估表明，所有三种 TCM 中（95%百分位数）暴露于农药残留的水平远低于可能造成健康风险的水平。然而，杀虫剂对累积暴露的贡献较大，尤其是辛硫磷，更令人担忧的是，检测到了几种禁用农药。这些结果对于评估 TCM 的安全性具有理论和实际价值，并可以提高其质量和安全性。
