College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Drug Design, Development, & Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
Future Med Chem. 2018 Nov;10(22):2659-2674. doi: 10.4155/fmc-2018-0208. Epub 2018 Nov 30.
Due to the impermeable structure and barrier function of the blood-brain barrier (BBB), the delivery of therapeutic molecules into the CNS is extremely limited. Nanodelivery systems are regarded as the most effective and versatile carriers for the CNS, as they can transport cargo molecules across the BBB via various mechanisms. This review emphasizes the multi-functionalization strategies of nanodelivery systems and combinatorial approaches for the delivery of therapeutic drugs and genes into the CNS. The characteristics and functions of the BBB and underlying mechanisms of molecular translocation across the BBB are also described.
由于血脑屏障（BBB）的不可渗透结构和屏障功能，治疗分子进入中枢神经系统的递送受到极大限制。纳米递药系统被认为是 CNS 最有效和多功能的载体，因为它们可以通过多种机制将货物分子递送到 BBB 中。本综述强调了纳米递药系统的多功能化策略和联合方法，用于将治疗药物和基因递送到中枢神经系统。还描述了 BBB 的特性和功能以及分子穿过 BBB 的转运的潜在机制。
