Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam.
Faculty of Pharmacy, Lac Hong University, Buu Long Ward, Bien Hoa City, Dong Nai Province 810000, Vietnam.
Int J Mol Sci. 2019 Sep 23;20(19):4706. doi: 10.3390/ijms20194706.
The development of natural phospholipids for nanostructured drug delivery systems has attracted much attention in the past decades. Lecithin that was derived from naturally occurring in soybeans (SL) has introduced some auspicious accomplishments to the drug carrying aspect, like effectual encapsulation, controlled release, and successful delivery of the curative factors to intracellular regions in which they procure these properties from their flexible physicochemical and biophysical properties, such as large aqueous center and biocompatible lipid, self-assembly, tunable properties, and high loading capacity. Despite the almost perfect properties as a drug carrier, liposome is known to be quite quickly eliminated from the body systems. The surface modification of liposomes has been investigated in many studies to overcome this drawback. In this review, we intensively discussed the surface-modified liposomes that enhancing the targeting, cellular uptake, and therapeutic response. Moreover, the recent applications of soy lecithin-derived liposome, focusing on cancer treatment, brain targeting, and vaccinology, are also summarized.
在过去几十年中，开发用于纳米结构药物传递系统的天然磷脂引起了广泛关注。从大豆中天然存在的卵磷脂（SL）在药物携带方面取得了一些可喜的成就，例如有效的封装、控制释放以及成功地将治疗因子递送到细胞内区域，这些区域从其灵活的物理化学和生物物理特性中获得了这些特性，例如大的水中心和生物相容的脂质、自组装、可调特性和高载药能力。尽管作为药物载体具有几乎完美的特性，但脂质体已知会很快从体内系统中消除。已经在许多研究中研究了脂质体的表面修饰以克服这一缺点。在这篇综述中，我们深入讨论了增强靶向性、细胞摄取和治疗反应的表面修饰脂质体。此外，还总结了大豆卵磷脂衍生的脂质体在癌症治疗、脑靶向和疫苗学方面的最新应用。
