Department of Nutrition and Dietetics, Kanagawa University of Human Service, Kanagawa 238-8522, Japan.
Department of Pharmacology, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.
Nutrients. 2018 Nov 29;10(12):1834. doi: 10.3390/nu10121834.
This study investigated whether the association between postprandial plasma glucose (PPG) is affected by five type 2 diabetes mellitus (T2DM) susceptibility genes, and whether four weeks of yogurt consumption would affect these responses. We performed a single-arm intervention study in young nondiabetic Japanese participants, who consumed 150 g yogurt daily for four weeks, after which a rice test meal containing 50 g carbohydrate was administered. PPG and postprandial serum insulin (PSI) were measured between 0 and 120 mins at baseline and after the intervention. Genetic risk was evaluated by weighted genetic risk score (GRS) according to published methodology, and participants were assigned to one of two groups ( = 17: L-GRS group and = 15: H-GRS group) according to the median of weighted GRS. At baseline, the H-GRS group had higher glucose area under the curve after intake of the test meal than the L-GRS group (2175 ± 248 mg/dL.min vs. 1348 ± 199 mg/dL.min, < 0.001), but there were no significant differences after the yogurt intervention. However, there was an improvement in PSI in the H-GRS group compared with baseline. These results suggest that habitual yogurt consumption may improve glucose and insulin responses in nondiabetic subjects who have genetically higher PPG.
本研究旨在探讨餐后血糖（PPG）是否受五种 2 型糖尿病（T2DM）易感基因的影响，以及四周酸奶摄入是否会影响这些反应。我们在年轻的非糖尿病日本参与者中进行了一项单臂干预研究，参与者每天摄入 150 克酸奶，四周后给予含有 50 克碳水化合物的米饭测试餐。在基线和干预后，测量 0 至 120 分钟时的 PPG 和餐后血清胰岛素（PSI）。根据已发表的方法，通过加权遗传风险评分（GRS）评估遗传风险，根据加权 GRS 的中位数将参与者分为两组（ = 17：L-GRS 组和 = 15：H-GRS 组）。在基线时，与 L-GRS 组相比，H-GRS 组摄入测试餐后的曲线下葡萄糖面积更高（2175 ± 248 mg/dL.min 比 1348 ± 199 mg/dL.min， < 0.001），但酸奶干预后无显著差异。然而，与基线相比，H-GRS 组的 PSI 有所改善。这些结果表明，习惯性酸奶摄入可能改善具有较高 PPG 遗传倾向的非糖尿病受试者的血糖和胰岛素反应。
