心脏手术患者 ICU 住院时间延长的预测作为识别心脏手术患者营养风险的有用方法:一项前瞻性观察研究的事后分析。
Prediction of Prolonged ICU Stay in Cardiac Surgery Patients as a Useful Method to Identify Nutrition Risk in Cardiac Surgery Patients: A Post Hoc Analysis of a Prospective Observational Study.
机构信息
Department of Intensive Care Medicine and 3CARE, Medical Faculty RWTH Aachen, Aachen, Germany.
Department of Anesthesiology and Intensive Care Medicine, Research Institute of Circulation Pathology, E. Meshalkin National Medical Research Centre, Novosibirsk, Russia.
出版信息
JPEN J Parenter Enteral Nutr. 2019 Aug;43(6):768-779. doi: 10.1002/jpen.1486. Epub 2018 Dec 2.
BACKGROUND
Cardiovascular surgery patients with a prolonged intensive care unit (ICU) stay may benefit most from early nutrition support. Using established scoring systems for nutrition assessment and operative risk stratification, we aimed to develop a model to predict a prolonged ICU stay ≥5 days in order to identify patients who will benefit from early nutrition interventions.
METHODS
This is a retrospective analysis of a prospective observational study of patients undergoing elective valvular, coronary artery bypass grafting, or combined cardiac surgery. The nutrition risk was assessed by well-established screening tools. Patients' preoperative EuroSCORE (European System for Cardiac Operative Risk Evaluation), primary disease, and intraoperative cardiopulmonary bypass (CPB) time were included as independent variables in a multivariate logistic regression analysis to predict a prolonged ICU stay (>4 days).
RESULTS
The number of cardiac surgery patients included was 1193. Multivariate analysis revealed that for prediction of ICU stay >4 days, both Nutritional Risk Screening 2002 (area under the curve (AUC): 0.716, P = .020) and Mini Nutritional Assessment (MNA) score (AUC: 0.715, P = .037) were significant, whereas for prediction of ICU stay >5 days, only the MNA score showed significant results (AUC: 0.762, P = .011).
CONCLUSION
Present data provide first evidence about the combined use of EuroSCORE, primary disease, CPB time, and nutrition risk screening tools for prediction of prolonged ICU stay in cardiac surgery patients. If prospectively evaluated in adequately designed studies, this model may help to identify patients with prolonged ICU stay to initiate early postoperative nutrition therapy and thus, facilitate an enhanced recovery.
背景
心血管手术患者 ICU 住院时间延长可能最受益于早期营养支持。使用已建立的营养评估和手术风险分层评分系统,我们旨在建立一种预测 ICU 住院时间延长≥5 天的模型,以确定需要早期营养干预的患者。
方法
这是一项对择期瓣膜、冠状动脉旁路移植术或联合心脏手术患者进行前瞻性观察研究的回顾性分析。采用成熟的筛查工具评估营养风险。将患者术前欧洲心脏手术风险评估系统评分(EuroSCORE)、主要疾病和术中体外循环(CPB)时间作为独立变量纳入多变量逻辑回归分析,以预测 ICU 住院时间延长(>4 天)。
结果
纳入的心脏手术患者数量为 1193 例。多变量分析显示,对于预测 ICU 住院时间>4 天,营养风险筛查 2002 评分(AUC:0.716,P=0.020)和微型营养评估(MNA)评分(AUC:0.715,P=0.037)均有显著意义,而对于预测 ICU 住院时间>5 天,仅 MNA 评分有显著意义(AUC:0.762,P=0.011)。
结论
目前的数据首次提供了关于联合使用欧洲心脏手术风险评估系统评分、主要疾病、CPB 时间和营养风险筛查工具预测心脏手术患者 ICU 住院时间延长的证据。如果在设计合理的前瞻性研究中进行评估,该模型可能有助于识别 ICU 住院时间延长的患者,从而启动术后早期营养治疗,促进康复。