Hibbs Stephen P, Brunskill Susan J, Donald Graham C, Saunders Heather D, Murphy Michael F
Department of Haematology, Queen's Hospital, Romford.
NHS Blood & Transplant.
Transfusion. 2019 Feb;59(2):574-581. doi: 10.1111/trf.15077. Epub 2018 Dec 2.
How do we decide which topics should be prioritized for research? The need for a robust process for prioritization by key stakeholders, and not just the researchers themselves, was recognized by the James Lind Alliance. A methodology has been established to enable clinicians, patients, and caregivers to identify and prioritize important uncertainties for research in different health areas. This methodology was applied to transfusion medicine to help focus the research agenda in this field.
A steering group was formed in 2015 comprising four donor/patient/caregiver representatives and six clinicians and was supported by an information scientist and James Lind Alliance representatives. The scope of the priority-setting partnership included uncertainties from blood donation through transfusion but excluded laboratory aspects of transfusion and specialist blood products. Three methods were used to identify the top 10 research priorities: two widely disseminated online surveys, a search of existing literature, and a final prioritization workshop.
There were 408 respondents to the first survey contributing 817 questions, which were refined into 54 indicative questions that had not already been answered by previous research. Respondents to a second survey were asked to select the three questions they believed to be the most important. The 30 most popular research questions were then brought to a workshop of donors, patients, and caregivers to produce the "top 10."
This prioritized list should be of considerable value to both researchers and funding bodies when considering what research should be conducted in transfusion medicine.
我们如何决定哪些主题应被优先用于研究？詹姆斯·林德联盟认识到，不仅研究人员自身，关键利益相关者也需要一个强有力的优先排序流程。已经建立了一种方法，使临床医生、患者和护理人员能够识别不同健康领域研究中的重要不确定性并对其进行优先排序。该方法被应用于输血医学，以帮助聚焦该领域的研究议程。
2015年成立了一个指导小组，由四名捐赠者/患者/护理人员代表和六名临床医生组成，并得到一名信息科学家和詹姆斯·林德联盟代表的支持。优先事项设定伙伴关系的范围包括从献血到输血过程中的不确定性，但不包括输血的实验室方面和特殊血液制品。使用三种方法确定了前10项研究优先事项：两项广泛传播的在线调查、对现有文献的检索以及一次最终优先排序研讨会。
第一次调查有408名受访者，提出了817个问题，这些问题被提炼成54个指示性问题，这些问题此前的研究尚未解答。第二次调查的受访者被要求选出他们认为最重要的三个问题。然后，将30个最受欢迎的研究问题提交给一个由捐赠者、患者和护理人员参加的研讨会，以确定“前10项”。
在考虑输血医学应开展哪些研究时，这份优先事项清单对研究人员和资助机构都应具有相当大的价值。
