Chen Nathan, Yang Seunghyeon, Leach Justin Morgan, Oh Jonghwa
Environmental Health Sciences, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Biostatistics, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Occup Environ Med. 2025 Apr 16;82(2):83-89. doi: 10.1136/oemed-2024-109979.
This study assessed finger blood flow (FBF) among groundskeepers using laser Doppler flowmetry (LDF) and evaluated the association of the FBF with hand-arm vibration (HAV) exposure dose.
Baseline FBF measured before a work shift (FBF) and daily changes in FBF before and after a work shift (ΔFBF) were measured among 17 groundskeepers and 10 office workers using LDF (PeriFlux 6000, Perimed, Järfälla, Sweden) for 3 days. Study participants' health-related information was obtained through questionnaires, while HAV exposure and demographic information were pulled from our previous study conducted in parallel with the present study. Linear mixed models were employed to estimate the association between HAV exposure dose and FBF.
The average FBF for right and left hands was 241.5 and 239.9 perfusion units (PUs), respectively, among the exposure group and 305.6 and 307.3 PU, respectively, among the reference group. The average ΔFBF for right and left hands was 44.2 and 25.4 PU, respectively, among the exposure group and -35.2 and -33.2 PU, respectively, among the reference group. A significant negative association between lifetime HAV exposure and FBF was observed in the linear mixed model after adjusting for age, body mass index, race/ethnicity and hypertension (right hand: β=-0.0006 and p=0.0055; left hand: β=-0.0009 and p=0.0068). Inconsistent significances were observed between lifetime HAV exposure and ΔFBF and between daily HAV exposure and ΔFBF.
A significant negative association between lifetime HAV exposure and baseline FBF among groundskeepers was observed, supporting FBF measurement using LDF as a promising health indicator for vascular disorders induced by HAV.
本研究使用激光多普勒血流仪（LDF）评估了场地管理员的手指血流量（FBF），并评估了FBF与手臂振动（HAV）暴露剂量之间的关联。
在17名场地管理员和10名办公室职员中，使用LDF（PeriFlux 6000，瑞典耶夫勒的Perimed公司）在3天内测量了轮班前测量的基线FBF（FBF）以及轮班前和轮班后FBF的每日变化（ΔFBF）。通过问卷调查获取研究参与者的健康相关信息，而HAV暴露和人口统计学信息则取自我们之前与本研究并行开展的研究。采用线性混合模型来估计HAV暴露剂量与FBF之间的关联。
暴露组右手和左手的平均FBF分别为241.5和239.9灌注单位（PU），参照组分别为305.6和307.3 PU。暴露组右手和左手的平均ΔFBF分别为44.2和25.4 PU，参照组分别为-35.2和-33.2 PU。在调整年龄、体重指数、种族/民族和高血压因素后，线性混合模型中观察到终生HAV暴露与FBF之间存在显著的负相关（右手：β=-0.0006，p=0.0055；左手：β=-0.0009，p=0.0068）。在终生HAV暴露与ΔFBF之间以及每日HAV暴露与ΔFBF之间观察到不一致的显著性。
观察到场地管理员终生HAV暴露与基线FBF之间存在显著的负相关，支持使用LDF测量FBF作为HAV引起的血管疾病的有前景的健康指标。
