Brady S F, Clardy J
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
J Nat Prod. 2000 Oct;63(10):1447-8. doi: 10.1021/np990568p.
Cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antifungal activity. CR377, a new pentaketide antifungal agent, was isolated from the culture broth of a fungus, CR377 (Fusarium sp.), that showed potent activity against Candida albicans in this assay. The structure of CR377 was established using 1- and 2-D NMR and HRFABMS.
对在哥斯达黎加瓜纳卡斯特保护区采集的内生真菌培养物进行了抗真菌活性筛选。从一种真菌CR377（镰刀菌属）的培养液中分离出一种新型五酮抗真菌剂CR377，该真菌在此试验中对白色念珠菌显示出强效活性。利用一维和二维核磁共振以及高分辨快原子轰击质谱确定了CR377的结构。
