Shi Liwei, Feng Ling, Yang Yanan, Li Xiaowen, Zhang Meizhen, Zhang Yueying, Ni Qing
Department of Endocrinology.
Department of Health Care, Guang'an Men Hospital, China Academy of Chinese Medical Sciences.
Medicine (Baltimore). 2018 Nov;97(48):e13355. doi: 10.1097/MD.0000000000013355.
Prediabetes is prevalent and significantly increases lifetime risk of progression to type 2 diabetes mellitus (T2DM). Acupuncture has been increasingly used for prediabetes in China but its effect is unclear. We aim to assess the efficacy and safety of acupuncture in preventing or delaying incident diabetes among individuals with prediabetes.
The following 8 databases will be searched from inception to September 1, 2018: the Cochrane Central Register of Controlled Trials (CENTRAL) on the Cochrane Library, PubMed, Embase, Chinese National Knowledge Infrastructure database, Chinese Biomedical Literature database, Chinese Scientific Journal database, Wan Fang database, and Clinical Trials. The incidence of diabetes and regression toward normoglycemia will be accepted as the primary outcomes. The Cochrane Risk of Bias tool will be used to evaluate the methodologic quality of eligible studies. Meta-analysis will be performed by Review Manager 5.3.
This study will provide a high-quality synthesis of current evidence of acupuncture in the prevention of T2DM from several aspects including the incidence of diabetes, regression toward normoglycemia, fasting plasma glucose, 2-hour plasma glucose level after a 75-g oral glucose tolerance test, glycosylated hemoglobin level, body mass index, and adverse drug events.
The conclusion of this review will provide evidence to judge whether acupuncture is an effective and safe intervention for prediabetes.
PROSPERO CRD42018111236.
糖尿病前期很常见，且显著增加进展为2型糖尿病（T2DM）的终生风险。在中国，针灸已越来越多地用于糖尿病前期，但疗效尚不清楚。我们旨在评估针灸在预防或延缓糖尿病前期个体发生糖尿病方面的疗效和安全性。
将检索以下8个数据库，检索时间从建库至2018年9月1日：Cochrane图书馆中的Cochrane对照试验中心注册库（CENTRAL）、PubMed、Embase、中国知网数据库、中国生物医学文献数据库、中国科学期刊数据库、万方数据库和临床试验数据库。糖尿病发病率和血糖恢复正常将作为主要结局指标。将使用Cochrane偏倚风险工具评估纳入研究的方法学质量。将通过Review Manager 5.3进行荟萃分析。
本研究将从糖尿病发病率、血糖恢复正常、空腹血糖、75g口服葡萄糖耐量试验后2小时血糖水平、糖化血红蛋白水平、体重指数和药物不良事件等多个方面，对目前针灸预防T2DM的证据进行高质量的综合分析。
本综述的结论将为判断针灸是否是一种有效且安全的糖尿病前期干预措施提供依据。
PROSPERO CRD42018111236。
