Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
Department of Life and Environmental Sciences, College of Natural and Health Sciences, Zayed University, P.O. Box 19282, Dubai, United Arab Emirates.
Biosci Rep. 2019 Jan 15;39(1). doi: 10.1042/BSR20181052. Print 2019 Jan 31.
Tumor necrosis factor-α (TNF-α), secreted by the activated macrophages, may participate in the onset and progression of colorectal cancer (CRC). The association of -α 308 G>A (rs1800629) single-nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive. A trial sequential meta-analysis was performed for precise estimation of the relationship between -α 308 G>A gene polymorphism with CRC risk.
Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were mined for relevant articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the significance of association.
The pooled analysis indicated no risk associated with -α 308 G>A SNP and overall CRC risk in five genetic comparison models, i.e. allelic (A vs. G: = 0.524; OR = 1.074, 95% CI = 0.863-1.335), homozygous (AA vs. GG: = 0.489; OR = 1.227, 95% CI = 0.688-2.188), heterozygous (AG vs. GG: = 0.811; OR = 1.024, 95% CI = 0.843-1.244), dominant (AA+AG vs. GG: = 0.630; OR = 1.055, 95% CI = 0.849-1.311) and recessive (AA vs. AG+GG: = 0.549; OR = 1.181, 95% CI = 0.686-2.033). Subgroup analysis revealed that -α 308 G>A SNP is associated with reduced risk of CRC in Asian ethnicity. The study showed no publication bias.
No association of -α 308 G>A SNP with overall CRC risk was found. This SNP is likely to be protective against CRC in Asian population when compared with Caucasian population. Larger prospective-epidemiological studies are warranted to elucidate the roles of α 308 G>A SNP in the etiology of CRC and to endorse the present findings.
肿瘤坏死因子-α（TNF-α）由活化的巨噬细胞分泌，可能参与结直肠癌（CRC）的发生和发展。已有许多研究探讨了-α 308 G>A（rs1800629）单核苷酸多态性（SNP）与 CRC 风险的关联，但结果尚无定论。本试验采用序贯meta 分析对-α 308 G>A 基因多态性与 CRC 风险的关系进行了精确估计。
检索 Medline（PubMed）、EMBASE（Excerpta-Medica）和 Google Scholar 以获取相关文献。采用比值比（ORs）和 95%置信区间（CIs）来计算关联的显著性。
五项遗传比较模型的汇总分析表明，-α 308 G>A SNP 与总体 CRC 风险无关，即等位基因（A 对 G：=0.524；OR=1.074，95%CI=0.863-1.335）、纯合子（AA 对 GG：=0.489；OR=1.227，95%CI=0.688-2.188）、杂合子（AG 对 GG：=0.811；OR=1.024，95%CI=0.843-1.244）、显性（AA+AG 对 GG：=0.630；OR=1.055，95%CI=0.849-1.311）和隐性（AA 对 AG+GG：=0.549；OR=1.181，95%CI=0.686-2.033）。亚组分析显示，-α 308 G>A SNP 与 CRC 风险降低相关。本研究未发现发表偏倚。
本研究未发现-α 308 G>A SNP 与总体 CRC 风险相关。与高加索人群相比，该 SNP 可能对亚洲人群 CRC 具有保护作用。需要更大规模的前瞻性流行病学研究来阐明-α 308 G>A SNP 在 CRC 病因学中的作用，并证实本研究的结果。
