Zollinger L, Potworowski E F
Scand J Immunol. 1977;6(12):1369-74. doi: 10.1111/j.1365-3083.1977.tb00380.x.
Two components of the thymic microenvironment have been separated, and their biological properties have been studied. The first component, soluble thymic factor (STF), after injection into syngeneic recipients, provoked a temporary decrease in thymic weight on day 7, concomitant with an increase in the level of T cells in lymph nodes (but not in the spleen), followed by a general hypertrophy of lymph nodes peaking on day 21. In contrast, after the injection of the second component, insoluble thymic fraction (ITF), there was an increase in the number of prothymocytes in the thymic subcapsulary cortex, followed by general thymic hypertrophy on days 14 and 21. STF is believed to trigger a selective migration of lymph-node-seeking T cells from the thymus, whereas ITF seems to play a role in the differentiation step preceding that imparted by STF.
胸腺微环境的两个组分已被分离出来，并对其生物学特性进行了研究。第一个组分是可溶性胸腺因子（STF），将其注射到同基因受体体内后，在第7天会引起胸腺重量暂时下降，同时淋巴结（而非脾脏）中T细胞水平升高，随后淋巴结普遍肥大，在第21天达到峰值。相比之下，注射第二个组分即不溶性胸腺组分（ITF）后，胸腺被膜下皮质中的前胸腺细胞数量增加，随后在第14天和第21天出现胸腺普遍肥大。据信，STF会触发胸腺中寻找淋巴结的T细胞选择性迁移，而ITF似乎在STF所赋予的分化步骤之前的那个分化步骤中发挥作用。
