Hofstra W, Welling G W, Van der Waaij D
Laboratory for Medical Microbiology, University of Groningen, The Netherlands.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Jul;269(1):78-85. doi: 10.1016/s0176-6724(88)80086-5.
Oral treatment of groups of four mice with different daily dosages of three related antibiotics, amoxycillin, augmentin and bacampicillin, has indicated the influence of the amount of the dose that reaches the intestine in a biologically active form. Augmentin (amoxycillin plus clavulanic acid to protect it against enzymatic hydrolysis) appeared to have a suppressive effect on the indigenous colonization-resistance-associated microflora. Dose-effect curves of amoxycillin alone, showed the same shape but at a lower level. Bacampicillin treatment practically did not have an effect on the faecal flora. Only at doses of bacampicillin of well above 1.5 mg per day, an indication was seen of CR-flora disturbance. At a dose level of 2 mg and more per day, a low concentration of beta-aspartylglycine was found in the faeces. A normal undisturbed intestinal flora normally produces in mice sufficient enzyme to degrade completely this dipeptide released by the host organism into the intestinal tract.
用三种相关抗生素阿莫西林、奥格门汀和巴坎西林的不同日剂量对每组四只小鼠进行口服治疗，结果表明以生物活性形式到达肠道的剂量量会产生影响。奥格门汀（阿莫西林加克拉维酸以保护其免受酶水解）似乎对与肠道定植抗性相关的本土微生物群有抑制作用。单独使用阿莫西林的剂量 - 效应曲线形状相同，但水平较低。巴坎西林治疗实际上对粪便菌群没有影响。仅在每天剂量远高于1.5毫克的情况下，才观察到CR菌群紊乱的迹象。在每天2毫克及以上的剂量水平下，在粪便中发现了低浓度的β - 天冬氨酰甘氨酸。正常未受干扰的肠道菌群通常在小鼠体内产生足够的酶，以完全降解宿主生物体释放到肠道中的这种二肽。
