Brumfitt W, Hamilton-Miller J M, Dixson S, Gargan R A, Gooding A
J Clin Pathol. 1983 Jun;36(6):670-3. doi: 10.1136/jcp.36.6.670.
Ampicillin was found to be some tenfold more active than amoxycillin against Enterobacter cloacae. This finding explains the observation that some Ent cloacae strains are sensitive to ampicillin in the disc test but resistant to Augmentin. Ampicillin was also found to be more active than amoxycillin against Citrobacter freundii and Serratia marcescens. In view of these findings, the practice of using ampicillin discs to predict sensitivity to amoxycillin should be reconsidered. The use of both ampicillin and amoxycillin discs is appropriate if errors are to be avoided.
已发现氨苄西林对阴沟肠杆菌的活性比阿莫西林高约十倍。这一发现解释了以下现象：在纸片扩散试验中，一些阴沟肠杆菌菌株对氨苄西林敏感，但对阿莫西林克拉维酸钾耐药。还发现氨苄西林对弗氏柠檬酸杆菌和黏质沙雷氏菌的活性也比阿莫西林高。鉴于这些发现，应重新考虑使用氨苄西林纸片来预测对阿莫西林敏感性的做法。如果要避免错误，同时使用氨苄西林和阿莫西林纸片是合适的。
