Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China,
Int J Nanomedicine. 2018 Nov 9;13:7349-7362. doi: 10.2147/IJN.S179678. eCollection 2018.
Cardiovascular diseases (CVDs) are one of the most important causes of mortality and affecting the health status of patients. At the same time, CVDs cause a huge health and economic burden to the whole world. Although a variety of therapeutic drugs and measures have been produced to delay the progress of the disease and improve the quality of life of patients, most of the traditional therapeutic strategies can only cure the symptoms and cannot repair or regenerate the damaged ischemic myocardium. In addition, they may bring some unpleasant side effects. Therefore, it is vital to find and explore new technologies and drugs to solve the shortcomings of conventional treatments. Nanotechnology is a new way of using and manipulating the matter at the molecular scale, whose functional organization is measured in nanometers. Because nanoscale phenomena play an important role in cell signal transduction, enzyme action and cell cycle, nanotechnology is closely related to medical research. The application of nanotechnology in the field of medicine provides an alternative and novel direction for the treatment of CVDs, and shows excellent performance in the field of targeted drug therapy and the development of biomaterials. This review will briefly introduce the latest applications of nanotechnology in the diagnosis and treatment of common CVDs.
心血管疾病(CVDs)是最重要的死亡原因之一,影响着患者的健康状况。同时,CVDs 给全世界带来了巨大的健康和经济负担。尽管已经产生了多种治疗药物和措施来延缓疾病的进展,提高患者的生活质量,但大多数传统的治疗策略只能治标不治本,无法修复或再生受损的缺血性心肌。此外,它们可能会带来一些不良反应。因此,寻找和探索新技术和药物来解决常规治疗的缺点至关重要。
纳米技术是一种利用和操纵分子尺度物质的新方法,其功能组织的测量单位为纳米。由于纳米尺度现象在细胞信号转导、酶作用和细胞周期中起着重要作用,因此纳米技术与医学研究密切相关。纳米技术在医学领域的应用为 CVDs 的治疗提供了一种替代和新颖的方向,并在靶向药物治疗和生物材料的开发领域表现出优异的性能。
这篇综述将简要介绍纳米技术在常见 CVDs 的诊断和治疗中的最新应用。