Prujansky A, Ravid A, Sharon N
Biochim Biophys Acta. 1978 Mar 21;508(1):137-46. doi: 10.1016/0005-2736(78)90195-5.
The relationship between the binding patterns of soybean agglutinin, peanut agglutinin (both in their native (unaggregated) form and in their polymerized form), and of Phaseolus vulgaris leucoagglutinin, to neuraminidase-treated lymphocytes from different sources, and the mitogenic activity of these lectins, was studied. In all cases investigated, binding of a lectin to lymphocytes which resulted in stimulation was a positive cooperative process. Our findings support the assumption that clustering of receptors and conformational changes in membrane structure are prerequisites for mitogenic stimulation.
研究了大豆凝集素、花生凝集素（天然（未聚合）形式和聚合形式）以及菜豆白细胞凝集素与来自不同来源的神经氨酸酶处理淋巴细胞的结合模式之间的关系，以及这些凝集素的促有丝分裂活性。在所有研究的案例中，凝集素与淋巴细胞的结合导致刺激是一个正协同过程。我们的研究结果支持这样的假设，即受体聚集和膜结构的构象变化是有丝分裂刺激的先决条件。
