分析树皮中原花青素的分布并评估其体外抗氧化和抗糖尿病潜力。
Analytical Profiling of Proanthocyanidins from Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential.
机构信息
Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Food Bioprocessing and Nutrition Sciences Department, Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, Kannapolis, NC 28081, USA.
出版信息
Molecules. 2018 Nov 6;23(11):2891. doi: 10.3390/molecules23112891.
The proanthocyanidins from ethanol extracts (80%, /) of () bark on chemical-based and cellular antioxidant activity assays as well as carbolytic enzyme inhibitory activities were studied. About 77% of oligomeric proanthocyanidins in ethanol extracts of bark were found by using normal-phase HPLC. In addition, HPLC-ESI-TOF/MS and MALDI-TOF/TOF MS analyses indicated that proanthocyanidins from bark exhibited with a degree of polymerization ranging from 1 to 11. These results of combined antioxidant activity assays, as well as carbolytic enzyme inhibitory activities of proanthocyanidins from bark, indicated an encouraging antioxidant capacity for the high polyphenol content and a potential for use as alternative drugs for lowering the glycemic response.
从 （）树皮的乙醇提取物（80%/）中提取的原花青素在基于化学和细胞的抗氧化活性测定以及裂解酶抑制活性方面进行了研究。通过使用正相 HPLC，发现 树皮乙醇提取物中有约 77%的低聚原花青素。此外，HPLC-ESI-TOF/MS 和 MALDI-TOF/TOF MS 分析表明，来自 树皮的原花青素具有聚合度从 1 到 11 的范围。这些综合抗氧化活性测定以及 树皮中原花青素的裂解酶抑制活性的结果表明，由于高多酚含量，其具有令人鼓舞的抗氧化能力，并且可能可作为降低血糖反应的替代药物。
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