Department of Public Health Solutions, Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland.
Department of Public Health Solutions, Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland.
Alzheimers Dement. 2019 Mar;15(3):410-417. doi: 10.1016/j.jalz.2018.10.001. Epub 2018 Dec 4.
Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age.
We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60-77 years) who were randomized to intensive multidomain intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed.
Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the intervention group (P = .008; P = .051 for groups combined).
Dietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.
健康饮食与更好认知之间的关联已得到充分证实，但目前的证据仅限于评估老年人采用饮食改变的效果。
我们通过芬兰老年干预研究来预防认知障碍和残疾（FINGER），调查了饮食变化的作用。该研究纳入了 1260 名高危参与者（60-77 岁），他们被随机分配到强化多领域干预组（包括饮食咨询）或常规健康咨询组，干预时间为 2 年。分析了对饮食建议的依从性和认知表现的平行过程潜在增长曲线。
基线时健康饮食的依从性预测了整体认知的改善，而与干预分配无关（P=.003）。饮食改善与执行功能的有益变化有关，特别是在干预组（P=.008；综合组 P=.051）。
干预期间开始的饮食变化与 2 年内执行功能的变化有关。长期的饮食对整体认知的影响更大。
