Shaw Ashley R, Honea Robyn, Mudaranthakam Dinesh Pal, Young Kate, Vidoni Eric D, Morris Jill K, Billinger Sandra, Key Mickeal N, Berkley-Patton Jannette, Burns Jeffrey M
Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA.
Am J Lifestyle Med. 2024 Oct 23:15598276241296052. doi: 10.1177/15598276241296052.
Alzheimer's disease (AD) disproportionately impacts Black Americans, who are three times more likely to develop AD. While heart-healthy diets have shown potential in reducing AD risk, research on adapted dietary interventions for Black American communities remains limited. This pilot study assessed the feasibility and acceptability of an adapted brain healthy diet intervention (MIND + SOUL) and explored changes in cardiometabolic risk and cognition. Twenty-nine participants completed the 12-week intervention, which included culturally tailored health education, cooking classes, health coaching, and groceries. Feasibility was assessed by attendance and retention rates, while acceptability was measured by two questionnaires. Participants had a mean age of 70.3, with 10.3% male. The intervention demonstrated high feasibility (89.3% retention) and acceptability (mean = 71.9, SD = 8.59), with meaningful improvements in body mass index (estimate = -0.54, = 0.009), dietary intake (estimate = 28.39, = 0.042), and executive function (estimate = 3.32, < 0.001). However, no significant changes in blood-based biomarkers were observed. The MIND + SOUL intervention demonstrated high feasibility and acceptability, improvements in body composition, cognitive function, and dietary behaviors, despite no significant changes in blood-based biomarkers. Findings suggest potential benefits for reducing AD risk factors and promoting healthy aging. Clinical Trials Registry: ClinicalTrials.Gov; NCT05414682.
阿尔茨海默病（AD）对美国黑人的影响尤为严重，他们患AD的可能性是其他人的三倍。虽然有益心脏健康的饮食已显示出降低AD风险的潜力，但针对美国黑人社区的适应性饮食干预研究仍然有限。这项试点研究评估了一种适应性脑健康饮食干预（MIND + SOUL）的可行性和可接受性，并探讨了心脏代谢风险和认知方面的变化。29名参与者完成了为期12周的干预，其中包括根据文化定制的健康教育、烹饪课程、健康指导和食品杂货。通过出勤率和留存率评估可行性，通过两份问卷衡量可接受性。参与者的平均年龄为70.3岁，男性占10.3%。该干预显示出高可行性（留存率89.3%）和可接受性（平均值 = 71.9，标准差 = 8.59），体重指数有显著改善（估计值 = -0.54，P = 0.009）、饮食摄入量（估计值 = 28.39，P = 0.042）和执行功能（估计值 = 3.32，P < 0.001）。然而，未观察到血液生物标志物有显著变化。尽管血液生物标志物没有显著变化，但MIND + SOUL干预显示出高可行性和可接受性，身体成分、认知功能和饮食行为均有改善。研究结果表明，该干预在降低AD风险因素和促进健康老龄化方面具有潜在益处。临床试验注册：ClinicalTrials.Gov；NCT05414682。
