Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Mar 15;211:125-131. doi: 10.1016/j.saa.2018.12.004. Epub 2018 Dec 4.
Hydrazine (NH) and fluoride ion (F) are regarded as environmental pollutants and potential carcinogens. A dual-functional fluorescent probe (probe 1) was developed for both F and NH with high selectivity and sensitivity. 1 was based on nucleophilic aromatic substitution reaction for NH detection and selective cleavage of 4-nitrobenzenesulphonyl group for the determination of F. The limits of detection of probe for F and NH were 77.82 nM and 29.34 nM, respectively, which are far below the threshold limit value (TLV) of United States Environmental Protection Agency (EPA). The home-made test strips of 1 provided the positive tool for F and gaseous NH in different system. And the confocal fluorescence images indicated that 1 can quantitatively detect NH in living PC12 cells. Promisingly, 1 has great prospects for NH imaging and determining in living system.
水合肼（NH）和氟离子（F）被认为是环境污染物和潜在的致癌物质。本文设计了一种对 F 和 NH 均具有高选择性和灵敏度的双功能荧光探针（探针 1）。探针 1 基于亲核芳香取代反应检测 NH，以及选择性切割 4-硝基苯磺酰基基团来测定 F。探针 1 对 F 和 NH 的检测限分别为 77.82 nM 和 29.34 nM，远低于美国环境保护署（EPA）的阈值限值（TLV）。探针 1 的自制测试条为不同体系中的 F 和气态 NH 提供了阳性工具。共聚焦荧光图像表明，探针 1 可以定量检测活 PC12 细胞中的 NH。有前景的是，探针 1 有望用于活体内 NH 的成像和检测。
