Stroescu Ramona F, Mărginean Otilia, Bizerea Teofana, Gafencu Mihai, Voicu Adrian, Doroș Gabriela
Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania.
Victor Babes University of Medicine and Pharmacy, Timișoara, Romania.
J Pediatr Endocrinol Metab. 2019 Jan 28;32(1):27-31. doi: 10.1515/jpem-2018-0378.
Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population. Methods A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology. The patients were divided into two groups, according to the presence of MetS. Results MetS was present in 27% of obese children. The groups were homogenous with respect to age, sex and body mass index (BMI). Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively). Conclusions hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in pediatric population.
肥胖是一种慢性炎症性疾病，其中瘦素、脂联素和C反应蛋白（CRP）发挥着重要作用。本研究旨在调查肥胖儿童中瘦素、脂联素和高敏C反应蛋白（hs-CRP）等肥胖标志物之间的关系，并确定这些脂肪因子是否为定义儿童代谢综合征（MetS）的重要标志物。方法：2013年7月至2014年6月期间，在蒂米什瓦拉的路易·图尔卡努儿童急诊医院糖尿病与营养疾病科、内分泌科和心脏病科对122例肥胖儿童进行了为期1年的横断面研究。根据是否存在代谢综合征将患者分为两组。结果：27%的肥胖儿童存在代谢综合征。两组在年龄、性别和体重指数（BMI）方面具有同质性。脂联素、瘦素和hs-CRP在代谢综合征组中均有显著变化（分别为p=0.04、p=0.04、p=0.01）。结论：hs-CRP、瘦素和脂联素可作为儿童心血管风险的预测指标。
