Microbial Chemistry and Medical Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Department of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
J Antibiot (Tokyo). 2019 Mar;72(3):134-140. doi: 10.1038/s41429-018-0128-x. Epub 2018 Dec 10.
Simpotentin, a new potentiator of amphotericin B activity against Candida albicans and Cryptococcus neoformans, was isolated from the culture broth of Simplicillium minatense FKI-4981 by Diaion HP-20 column chromatography, centrifugal partition chromatography, and preparative HPLC. The structure of simpotentin was elucidated by spectroscopic analyses including NMR and MS. The compound has a mannose core to which two medium-chain fatty acids are linked. Simpotentin was found to potentiate amphotericin B activity against C. albicans by the microdilution method.
辛波亭是一种新型棘白菌素 B 活性增强剂，对白色念珠菌和新型隐球菌具有活性，从光滑拟青霉 FKI-4981 的发酵液中通过 Diaion HP-20 柱层析、离心分配色谱和制备 HPLC 分离得到。通过包括 NMR 和 MS 在内的光谱分析阐明了辛波亭的结构。该化合物具有一个甘露糖核心，其上连接有两个中链脂肪酸。通过微量稀释法发现辛波亭能增强两性霉素 B 对白色念珠菌的活性。
