Jenks P J, Caul E O, Roome A P
Public Health Laboratory, Kingsdown, Bristol.
Epidemiol Infect. 1988 Oct;101(2):473-6. doi: 10.1017/s095026880005442x.
Measles antibody titres were established in three groups of infants: children of vaccinated mothers, children of unvaccinated mothers and neonates born after different gestational periods. Lower measles antibody titres were observed in children whose mothers had been vaccinated, and these decayed to undetectable values earlier than in children whose mothers had not been vaccinated, and were assumed to have had natural measles. Lower measles antibody titres were observed in premature neonates than in full term babies, and these lower antibody levels will presumably decay to undetectable values earlier than in full term neonates. These results, if confirmed by larger studies, would indicate an earlier optimum age for vaccination against measles than the currently recommended 13-15 months for two groups in order to reduce the risk of natural infection before immunization. These groups are children in a highly vaccinated population whose mothers have a low measles antibody titre and premature children (defined as having a gestational period of less than 37 weeks).
母亲接种过疫苗的儿童、母亲未接种过疫苗的儿童以及在不同孕周后出生的新生儿。母亲接种过疫苗的儿童体内的麻疹抗体滴度较低，且这些抗体滴度比母亲未接种过疫苗（假定曾患自然麻疹）的儿童更早衰减至无法检测到的值。早产新生儿的麻疹抗体滴度低于足月儿，并且这些较低的抗体水平可能比足月儿更早衰减至无法检测到的值。如果更大规模的研究证实了这些结果，那么对于两组人群而言，为降低免疫前自然感染的风险，麻疹疫苗接种的最佳年龄可能要早于目前推荐的13至15个月。这两组人群分别是母亲麻疹抗体滴度较低的高疫苗接种率人群中的儿童以及早产儿（定义为孕周小于37周）。
