Lennon J L, Black F L
J Pediatr. 1986 May;108(5 Pt 1):671-6. doi: 10.1016/s0022-3476(86)81039-3.
Measles hemagglutinin-inhibiting and neutralizing antibody titers are lower in women young enough to have been immunized by vaccination than in older women. In the children of both young and older mothers the antibody is concentrated 1.7-fold across the placenta, and the child's initial titer remains proportional to that of its mother. The transferred antibody is diluted by the baby's growth and degraded with a mean half-life of 48 days. By 8 1/2 months of age, 95% of the children of the mothers born since 1963 would have become susceptible to measles and responsive to immunization; the same level of susceptibility is not reached by children of mothers born before 1958 until 11 1/2 months of age. Among the offspring of younger mothers, a small group remains, about 2% of the total, with titers high enough to provide protection for 12 months, and these children would be poorly served if the age for vaccination were reduced for all. However, selective early vaccination of children of young mothers who have low antibody titers would eliminate an important focus of measles susceptibility.
与年长女性相比，年龄小到足以接种疫苗的女性的麻疹血凝抑制抗体和中和抗体滴度较低。在年轻母亲和年长母亲的孩子中，抗体通过胎盘浓缩1.7倍，孩子的初始滴度仍与母亲的滴度成比例。转移的抗体因婴儿生长而稀释，平均半衰期为48天。到8个半月大时，1963年以后出生的母亲的孩子中有95%会对麻疹易感并对免疫有反应；1958年以前出生的母亲的孩子直到11个半月大时才达到相同的易感性水平。在年轻母亲的后代中，一小部分人（约占总数的2%）的滴度足够高，足以提供12个月的保护，如果对所有人都降低接种年龄，这些孩子将得不到充分的保护。然而，对抗体滴度低的年轻母亲的孩子进行选择性早期接种将消除麻疹易感性的一个重要焦点。
