长链非编码RNA与肌萎缩侧索硬化症：仍有许多工作要做。
Long non coding RNAs and ALS: Still much to do.
作者信息
Gagliardi Stella, Pandini Cecilia, Garofalo Maria, Bordoni Matteo, Pansarasa Orietta, Cereda Cristina
机构信息
Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
出版信息
Noncoding RNA Res. 2018 Nov 15;3(4):226-231. doi: 10.1016/j.ncrna.2018.11.004. eCollection 2018 Dec.
Abstract
Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated to ALS demonstrating that how there is still much to do to identify and understand their role in ALS. This class of RNAs may offer numerous starting points for new investigations about pathogenic mechanism involved in ALS disease. In this review, we have collected all the presented data about lncRNAs and ALS to offer an overview about this class of non-coding RNAs and their possible role in ALS disease.
摘要
RNA代谢改变在肌萎缩侧索硬化症（ALS）发病机制中起重要作用。迄今为止，文献中已描述了少数与ALS相关的长链非编码RNA（lncRNA），这表明在鉴定和了解它们在ALS中的作用方面仍有许多工作要做。这类RNA可能为有关ALS疾病致病机制的新研究提供众多切入点。在本综述中，我们收集了所有关于lncRNA和ALS的现有数据，以概述这类非编码RNA及其在ALS疾病中的可能作用。
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本文引用的文献
1
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Noncoding RNA Res. 2018 Sep 10;3(4):178-187. doi: 10.1016/j.ncrna.2018.09.001. eCollection 2018 Dec.
2
Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.转录延伸复合物非编码 RNA 靶标的异常激活导致 TDP-43 毒性。
Nat Commun. 2018 Oct 23;9(1):4406. doi: 10.1038/s41467-018-06543-0.
3
Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.TDP-43 功能丧失导致肌萎缩侧索硬化症中保护性副核小体超组装。
Mol Neurodegener. 2018 Jun 1;13(1):30. doi: 10.1186/s13024-018-0263-7.
4
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Int J Mol Sci. 2018 May 3;19(5):1345. doi: 10.3390/ijms19051345.
5
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Sci Rep. 2018 Mar 6;8(1):4049. doi: 10.1038/s41598-018-21371-4.
6
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Stem Cell Res. 2018 Mar;27:172-179. doi: 10.1016/j.scr.2018.01.037. Epub 2018 Jan 31.
7
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8
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Nat Med. 2018 Mar;24(3):313-325. doi: 10.1038/nm.4490. Epub 2018 Feb 5.
9
Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.在 C9orf72 相关肌萎缩侧索硬化症/额颞叶痴呆的果蝇模型中， sense 和 antisense RNA 没有毒性。
Acta Neuropathol. 2018 Mar;135(3):445-457. doi: 10.1007/s00401-017-1798-3. Epub 2018 Jan 29.
10
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Front Neurosci. 2017 Dec 15;11:711. doi: 10.3389/fnins.2017.00711. eCollection 2017.
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