Gagliardi Stella, Pandini Cecilia, Garofalo Maria, Bordoni Matteo, Pansarasa Orietta, Cereda Cristina
Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Noncoding RNA Res. 2018 Nov 15;3(4):226-231. doi: 10.1016/j.ncrna.2018.11.004. eCollection 2018 Dec.
Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated to ALS demonstrating that how there is still much to do to identify and understand their role in ALS. This class of RNAs may offer numerous starting points for new investigations about pathogenic mechanism involved in ALS disease. In this review, we have collected all the presented data about lncRNAs and ALS to offer an overview about this class of non-coding RNAs and their possible role in ALS disease.
RNA代谢改变在肌萎缩侧索硬化症（ALS）发病机制中起重要作用。迄今为止，文献中已描述了少数与ALS相关的长链非编码RNA（lncRNA），这表明在鉴定和了解它们在ALS中的作用方面仍有许多工作要做。这类RNA可能为有关ALS疾病致病机制的新研究提供众多切入点。在本综述中，我们收集了所有关于lncRNA和ALS的现有数据，以概述这类非编码RNA及其在ALS疾病中的可能作用。
