Zhang Lei, Ding Zhimin, Dong Fajin, Wu Huaiyu, Liang Weiyu, Tian Hongtian, Ye Xiuqin, Luo Hui, Xu Jinfeng
Department of Ultrasound, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People's Hospital, Shenzhen, China.
Department of Ultrasound, Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Front Pharmacol. 2018 Nov 26;9:1359. doi: 10.3389/fphar.2018.01359. eCollection 2018.
This study evaluated the ability of Sound Touch Elastography (STE) to distinguish malignant from benign thyroid nodules by quantifying tumor stiffness using the elastic ratio (EI) and shear modulus (G). Eighty-six patients with 86 nodules were enrolled in this study. There were 24/86 (27.90%) thyroid papillary carcinomas (TPC) and 62/86 (72.10%) benign nodules. The mean EI was significantly lower in TPCs than in benign nodules. The EI area under the receiver operating characteristic curve (ROC) was 80%. The EI cutoff value for TPCs was 0.215%. The sensitivity (Sen), specificity (Spe), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) were 71%, 73%, 2.58, and 0.40, respectively. , , and were significantly higher in TPCs than in benign nodules. There were no significant differences in . Compared with other G parameters, with an optimal cutoff value of 15.82 kPa had the highest AUROC value (84%). The Sen, Spe, LR+, and LR- were 79.17%, 79.03%, 3.776, and 0.261, respectively. We pooled the EI, , , and and the pooled-Sen, Spe, LR+, LR-, diagnostic odds ratio and odds ratio, and area under the summary ROC were 79%, 71%, 2.73, 0.29, 2.23, 9.29, and 82%, respectively. STE could be a new ultrasound diagnostic method for evaluating benign and malignant thyroid nodules.
本研究通过使用弹性比（EI）和剪切模量（G）量化肿瘤硬度，评估了超声弹性成像（STE）区分甲状腺恶性结节与良性结节的能力。本研究纳入了86例患有86个结节的患者。其中有24/86（27.90%）例甲状腺乳头状癌（TPC）和62/86（72.10%）例良性结节。TPC的平均EI显著低于良性结节。EI的受试者工作特征曲线（ROC）下面积为80%。TPC的EI临界值为0.215%。灵敏度（Sen）、特异度（Spe）、阳性似然比（LR+）和阴性似然比（LR-）分别为71%、73%、2.58和0.40。TPC中的[具体指标1]、[具体指标2]和[具体指标3]显著高于良性结节。[另一具体指标]无显著差异。与其他G参数相比，最佳临界值为15.82 kPa的[具体G参数]具有最高的曲线下面积（AUROC）值（84%）。Sen、Spe、LR+和LR-分别为79.17%、79.03%、3.776和0.261。我们汇总了EI、[具体指标1]、[具体指标2]和[具体指标3]，汇总后的Sen、Spe、LR+、LR-、诊断比值比和比值比以及汇总ROC曲线下面积分别为79%、71%、2.73、0.29、2.23、9.29和82%。超声弹性成像可成为评估甲状腺结节良恶性的一种新型超声诊断方法。
