Peyroux Elodie, Prost Zelda, Danset-Alexandre Charlotte, Brenugat-Herne Lindsay, Carteau-Martin Isabelle, Gaudelus Baptiste, Jantac Célia, Attali David, Amado Isabelle, Graux Jérôme, Houy-Durand Emmanuelle, Plasse Julien, Franck Nicolas
University Department of Rehabilitation (SUR-CL3R), Le Vinatier hospital, 4 rue Jean Sarrazin, 69008 Lyon, France.
Reference Center for Rare Diseases (GénoPsy), Le Vinatier hospital, 95 Bd Pinel, 69500 Bron, France.
Schizophr Res Cogn. 2018 Nov 8;15:21-29. doi: 10.1016/j.scog.2018.10.001. eCollection 2019 Mar.
Interactions between social cognition and symptoms of schizophrenia have been investigated, but mostly component by component. Here we tested the assumption that two categories of deficits exist depending on clinical profiles, one corresponding to a defect in social cognition - "under-social cognition" - and one corresponding to excessive attributions leading to social cognitive impairments - "over-social cognition". To conduct the investigation, we performed a Hierarchical Clustering Analysis using positive and negative symptoms in seventy patients with schizophrenia and we compared the clusters obtained to a group of healthy controls on social cognitive measures. We distinguished two social cognitive profiles based on prevailing symptoms for emotion processes and Theory of Mind. Actually, patients with negative symptoms showed lower performances in emotion recognition task than both those with positive symptoms and controls. Concerning Theory of Mind, patients with positive symptoms had a significant tendency to make over interpretative errors than both patients with negative symptoms and controls. For other processes assessed, further explorations are needed. Actually, concerning social perception and knowledge both patients' groups presented significant impairments compared to controls. Assessment of attribution bias showed that patients in the positive group presented a significant hostility bias and a higher intentionality score compared to healthy controls. These results favor the existence of different categories of impairments depending more on the clinical characteristics of patients than on nosographical categories, but further investigations are now necessary to specify these profiles. It nevertheless showed the importance of assessing symptoms in relationship with cognitive functioning.
社会认知与精神分裂症症状之间的相互作用已得到研究，但大多是逐个成分进行的。在此，我们检验了这样一种假设，即根据临床特征存在两类缺陷，一类对应于社会认知缺陷——“社会认知不足”，另一类对应于导致社会认知障碍的过度归因——“社会认知过度”。为了进行这项研究，我们对70例精神分裂症患者的阳性和阴性症状进行了层次聚类分析，并将得到的聚类与一组健康对照在社会认知测量方面进行了比较。我们根据情感过程和心理理论的主要症状区分了两种社会认知概况。实际上，阴性症状患者在情感识别任务中的表现低于阳性症状患者和对照组。关于心理理论，阳性症状患者比阴性症状患者和对照组更有做出过度解释性错误的显著倾向。对于所评估的其他过程，还需要进一步探索。实际上，关于社会感知和知识，两组患者与对照组相比均存在显著损害。归因偏差评估表明，与健康对照相比，阳性组患者存在显著的敌意偏差和更高的意向性得分。这些结果支持存在不同类别的损害，更多地取决于患者的临床特征而非疾病分类，但现在需要进一步研究来明确这些概况。然而，这也表明了评估症状与认知功能关系的重要性。
