人单核吞噬细胞在经完整卡介苗和分枝杆菌抗原刺激后体外肿瘤坏死因子的表达。
Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens.
作者信息
Valone S E, Rich E A, Wallis R S, Ellner J J
机构信息
Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
出版信息
Infect Immun. 1988 Dec;56(12):3313-5. doi: 10.1128/iai.56.12.3313-3315.1988.
Abstract
Four mycobacterial preparations directly stimulated human blood monocytes and alveolar macrophages to produce tumor necrosis factor (TNF). Monoclonal antibody against TNF blocked (99%) TNF activity. Lipopolysaccharide was not responsible for the TNF activity generated; activity was unaffected in the presence of polymyxin B.
摘要
四种分枝杆菌制剂可直接刺激人血单核细胞和肺泡巨噬细胞产生肿瘤坏死因子（TNF）。抗TNF单克隆抗体可阻断（99%）TNF活性。脂多糖与所产生的TNF活性无关；在多粘菌素B存在的情况下，活性不受影响。
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