Departamento de Endocrinología y Metabolismo, and.
Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Am J Clin Nutr. 2018 Sep 1;108(3):485-491. doi: 10.1093/ajcn/nqy152.
Recently, the absence of metabolic effects from nonnutritive sweeteners has been questioned.
The aim of this study was to evaluate the effects of sucralose consumption on glucose metabolism variables.
We performed a randomized controlled trial involving healthy subjects without comorbidities and with a low habitual consumption of nonnutritive sweeteners (n = 33/group).
The intervention consisted of sucralose consumption as 15% of Acceptable Daily Intake every day for 14 d using commercial sachets. The control group followed the same procedures without any intervention. The glucose metabolism variables (insulin sensitivity, acute insulin response to glucose, disposition index, and glucose effectiveness) were evaluated by using a 3-h modified intravenous-glucose-tolerance test before and after the intervention period.
Individuals assigned to sucralose consumption showed a significant decrease in insulin sensitivity with a median (IQR) percentage change of -17.7% (-29.3% to -1.0%) in comparison to -2.8% (-30.7% to 40.6%) in the control group (P= 0.04). An increased acute insulin response to glucose from 577 mU · L-1· min (350-1040 mU · L-1· min) to 671 mU · L-1· min (376-1010 mU · L-1· min) (P = 0.04) was observed in the sucralose group for participants with adequate adherence.
Sucralose may have effects on glucose metabolism, and our study complements findings previously reported in other trials. Further studies are needed to confirm the decrease in insulin sensitivity and to explore the mechanisms for these metabolic alterations. This trial was registered at www.clinicaltrials.gov as NCT02589002.
最近，人们对非营养性甜味剂是否会对代谢产生影响提出了质疑。
本研究旨在评估三氯蔗糖摄入对葡萄糖代谢变量的影响。
我们进行了一项随机对照试验，纳入了无合并症且习惯性摄入非营养性甜味剂较少的健康受试者（每组 33 人）。
干预措施为每天使用商业小袋摄入 15%可接受日摄入量的三氯蔗糖，持续 14 天。对照组遵循相同的程序，但不进行任何干预。在干预前后，使用 3 小时改良静脉葡萄糖耐量试验评估葡萄糖代谢变量（胰岛素敏感性、葡萄糖急性胰岛素反应、处置指数和葡萄糖有效性）。
与对照组相比（-2.8%[-30.7%至 40.6%]），摄入三氯蔗糖的个体胰岛素敏感性显著下降，中位数（IQR）百分比变化为-17.7%[-29.3%至-1.0%]（P=0.04）。在依从性良好的参与者中，急性胰岛素对葡萄糖的反应从 577 mU·L-1·min（350-1040 mU·L-1·min）增加到 671 mU·L-1·min（376-1010 mU·L-1·min）（P=0.04）。
三氯蔗糖可能对葡萄糖代谢有影响，我们的研究补充了先前在其他试验中报告的发现。需要进一步的研究来证实胰岛素敏感性的下降，并探索这些代谢变化的机制。本试验在 www.clinicaltrials.gov 注册为 NCT02589002。
