Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.
Clinical Nutrition Division, General Hospital of Mexico Dr. Eduardo Liceaga, Mexico City, Mexico.
Nutr J. 2020 Apr 13;19(1):32. doi: 10.1186/s12937-020-00549-5.
Non-nutritive sweeteners (NNS) are widely consumed by humans due to their apparent innocuity, especially sucralose. However, several studies link sucralose consumption to weight gain and metabolic derangements, although data are still contradictory.
To determine the effect of acute and chronic consumption of sucralose on insulin and glucose profiles in young healthy adults.
This was a randomized, parallel, double-blind, placebo-controlled trial conducted in healthy young adults from 18 to 35 years old, without insulin resistance. A hundred thirty seven participants were randomized into three groups: a) volunteers receiving 48 mg sucralose, b) volunteers receiving 96 mg sucralose, and c) controls receiving water as placebo. All participants underwent a 3-h oral glucose tolerance test (OGTT) preceded by consuming sucralose or placebo 15 min before glucose load, at two time points: week zero (Wk0) and week ten (Wk10). Serum insulin and glucose were measured every 15 min during both OGTTs.
Compared to Wk0, consumption of sucralose for 10 weeks provoked 1) increased insulin concentrations at 0 min (7.5 ± 3.4 vs 8.8 ± 4.1 μIU/mL; p = 0.01), 30 min (91.3 ± 56.2 vs 110.1 ± 49.4 μIU/mL; p = 0.05), 105 min (47.7 ± 24.4 vs 64.3 ± 48.2 μIU/mL; p = 0.04) and 120 min (44.8 ± 22.1 vs 63.1 ± 47.8 μIU/mL; p = 0.01) in the 48 mg sucralose group; 2) increased blood glucose at - 15 min (87.9 ± 4.6 vs 91.4 ± 5.4 mg/dL; p = 0.003), 0 min (88.7 ± 4 vs 91.3 ± 6 mg/dL; p = 0.04) and 120 min (95.2 ± 23.7 vs 106.9 ± 19.5 mg/dL; p = 0.009) in the 48 mg sucralose group; 3) increased area under the curve (AUC) of insulin in both 48 and 96 mg sucralose groups (9262 vs 11,398; p = 0.02 and 6962 vs 8394; p = 0.12, respectively); and 4) reduced Matsuda index in the 48 mg sucralose group (6.04 ± 3.19 vs 4.86 ± 2.13; p = 0.01).
These data show that chronic consumption of sucralose can affect insulin and glucose responses in non-insulin resistant healthy young adults with normal body mass index (between 18.5 and 24.9 kg/m), however, the effects are not consistent with dose; further research is required.
NCT03703141.
由于非营养性甜味剂（NNS）的明显无害性，特别是三氯蔗糖，因此它们被人类广泛食用。然而，有几项研究将三氯蔗糖的摄入与体重增加和代谢紊乱联系起来，尽管数据仍然存在矛盾。
确定急性和慢性摄入三氯蔗糖对年轻健康成年人胰岛素和血糖谱的影响。
这是一项在 18 至 35 岁的健康年轻成年人中进行的随机、平行、双盲、安慰剂对照试验，这些成年人没有胰岛素抵抗。137 名参与者被随机分为三组：a）接受 48mg 三氯蔗糖的志愿者，b）接受 96mg 三氯蔗糖的志愿者，和 c）接受水作为安慰剂的对照组。所有参与者在口服葡萄糖耐量试验（OGTT）前 15 分钟内接受三氯蔗糖或安慰剂，在两个时间点进行：零周（Wk0）和第十周（Wk10）。在两次 OGTT 期间，每 15 分钟测量一次血清胰岛素和葡萄糖。
与 Wk0 相比，10 周内摄入三氯蔗糖会导致：1）48mg 三氯蔗糖组的胰岛素浓度在 0 分钟（7.5±3.4 与 8.8±4.1 μIU/mL；p=0.01）、30 分钟（91.3±56.2 与 110.1±49.4 μIU/mL；p=0.05）、105 分钟（47.7±24.4 与 64.3±48.2 μIU/mL；p=0.04）和 120 分钟（44.8±22.1 与 63.1±47.8 μIU/mL；p=0.01）时增加；2）48mg 三氯蔗糖组在-15 分钟（87.9±4.6 与 91.4±5.4mg/dL；p=0.003）、0 分钟（88.7±4 与 91.3±6mg/dL；p=0.04）和 120 分钟（95.2±23.7 与 106.9±19.5mg/dL；p=0.009）时血糖升高；3）48 和 96mg 三氯蔗糖组的胰岛素曲线下面积（AUC）增加（9262 与 11398；p=0.02 和 6962 与 8394；p=0.12）；和 4）48mg 三氯蔗糖组的 Matsuda 指数降低（6.04±3.19 与 4.86±2.13；p=0.01）。
这些数据表明，慢性摄入三氯蔗糖可能会影响非胰岛素抵抗的健康年轻成年人（BMI 在 18.5 至 24.9kg/m 之间）的胰岛素和血糖反应，但这些影响与剂量不一致；需要进一步研究。
NCT03703141。
