Department of Food and Human Nutritional Sciences, Richardson Centre for Functional Foods and Nutraceuticals, Faculty of Agriculture and Food Sciences, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.
Department of Community Health Sciences, University of Manitoba, Rady Faculty of Health Sciences, Winnipeg, MB R3T 6C5, Canada.
Appl Physiol Nutr Metab. 2020 Jun;45(6):606-612. doi: 10.1139/apnm-2019-0359. Epub 2019 Nov 7.
This study aimed to determine the effect of pure forms of sucralose and aspartame, in doses reflective of common consumption, on glucose metabolism. Healthy participants consumed pure forms of a non-nutritive sweetener (NNS) that were mixed with water and standardized to doses of 14% (0.425 g) of the acceptable daily intake (ADI) for aspartame and 20% (0.136 g) of the ADI for sucralose every day for 2 weeks. Blood samples were collected and analyzed for glucose, insulin, active glucagon-like peptide-1 (GLP-1), and leptin. Seventeen participants (10 females and 7 males; age, 24 ± 6.8 years; body mass index, 22.9 ± 2.5 kg/m) participated in the study. The total area under the curve values of glucose, insulin, active GLP-1 and leptin were similar for the aspartame and sucralose treatment groups compared with the baseline values in healthy participants. There was no change in insulin sensitivity after NNS treatment compared with the baseline values. These findings suggest that daily repeated consumption of pure sucralose or aspartame for 2 weeks had no effect on glucose metabolism among normoglycaemic adults. However, these results need to be tested in studies with longer durations. Daily consumption of pure aspartame or sucralose for 2 weeks had no effect on glucose metabolism. Daily consumption of pure aspartame or sucralose for 2 weeks had no effect on insulin sensitivity among healthy adults.
本研究旨在确定蔗糖素和阿斯巴甜的纯形式在反映常见摄入量的剂量下对葡萄糖代谢的影响。健康参与者每天摄入混合水并标准化至可接受日摄入量（ADI）的 14%（0.425 克）的非营养性甜味剂（NNS）的纯形式，对于阿斯巴甜和 20%（0.136 克）的蔗糖素，持续 2 周。采集血液样本并分析葡萄糖、胰岛素、活性胰高血糖素样肽-1（GLP-1）和瘦素。17 名参与者（10 名女性和 7 名男性；年龄，24 ± 6.8 岁；体重指数，22.9 ± 2.5 kg/m）参加了这项研究。与健康参与者的基线值相比，阿斯巴甜和蔗糖素治疗组的葡萄糖、胰岛素、活性 GLP-1 和瘦素的总曲线下面积值相似。与基线值相比，NNS 治疗后胰岛素敏感性没有变化。这些发现表明，在 2 周内每天重复摄入纯蔗糖素或阿斯巴甜对血糖代谢没有影响。然而，这些结果需要在持续时间更长的研究中进行测试。在 2 周内，每天食用纯阿斯巴甜或蔗糖素对葡萄糖代谢没有影响。在 2 周内，每天食用纯阿斯巴甜或蔗糖素对健康成年人的胰岛素敏感性没有影响。
