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1
Disseminated infection caused by urease-negative Cryptococcus neoformans.由脲酶阴性新型隐球菌引起的播散性感染。
J Clin Microbiol. 1988 Oct;26(10):2224-5. doi: 10.1128/jcm.26.10.2224-2225.1988.
2
The brown colour effect (BCE) of Cryptococcus neoformans in the diagnosis, control and epidemiology of C. neoformans infections in AIDS patients.新型隐球菌的棕色色素效应(BCE)在艾滋病患者新型隐球菌感染的诊断、控制及流行病学中的作用
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Aug;266(1-2):167-77. doi: 10.1016/s0176-6724(87)80030-5.
3
Failure of the Bactec 460 radiometer to detect Cryptococcus neoformans fungemia in an AIDS patient.Bactec 460 放射测量仪未能检测出一名艾滋病患者的新型隐球菌菌血症。
Am J Clin Pathol. 1987 Jun;87(6):783-6. doi: 10.1093/ajcp/87.6.783.
4
[An urease negative Cryptococcus neoformans].[一株脲酶阴性新型隐球菌]
Wei Sheng Wu Xue Bao. 1992 Feb;32(1):68-71.
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Cryptococcosis produced by a urease negative strain of Cryptococcus neoformans.由新型隐球菌脲酶阴性菌株引起的隐球菌病。
J Med Vet Mycol. 1993;31(1):87-9.
6
Clinical isolates of Cryptococcus neoformans from Zaire.来自扎伊尔的新型隐球菌临床分离株。
Eur J Clin Microbiol. 1986 Feb;5(1):50-1. doi: 10.1007/BF02013464.
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[Urease activity in Cryptococcus neoformans and Cryptococcus gattii].[新型隐球菌和格特隐球菌中的脲酶活性]
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Isolation of Cryptococcus neoformans gattii from a patient with AIDS in southern California.从南加州一名艾滋病患者体内分离出新型隐球菌格特变种。
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The variety of Cryptococcus neoformans in patients with AIDS.艾滋病患者中新隐球菌的种类。
J Infect Dis. 1986 Dec;154(6):1042. doi: 10.1093/infdis/154.6.1042.
10
Identification of a novel gene, URE2, that functionally complements a urease-negative clinical strain of Cryptococcus neoformans.一种新基因URE2的鉴定,该基因可功能性互补新型隐球菌脲酶阴性临床菌株。
Microbiology (Reading). 2006 Dec;152(Pt 12):3723-3731. doi: 10.1099/mic.0.2006/000133-0.

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Virulence-Associated Enzymes of Cryptococcus neoformans.新型隐球菌的毒力相关酶
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Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion.斑马鱼感染模型中宿主-寄生虫相互作用的实时成像揭示了新型隐球菌的毒力决定因素和中枢神经系统侵袭情况。
mBio. 2015 Sep 29;6(5):e01425-15. doi: 10.1128/mBio.01425-15.
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Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species.人类致病隐球菌物种中氮源依赖性荚膜诱导
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Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system.鉴定与真菌病原体新生隐球菌向中枢神经系统迁移相关的基因。
PLoS One. 2012;7(9):e45083. doi: 10.1371/journal.pone.0045083. Epub 2012 Sep 20.
5
Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.新型隐球菌的脲酶表达促进微血管隔离,从而增强对中枢神经系统的侵袭。
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Urease as a virulence factor in experimental cryptococcosis.脲酶作为实验性隐球菌病中的一种毒力因子。
Infect Immun. 2000 Feb;68(2):443-8. doi: 10.1128/IAI.68.2.443-448.2000.
7
A rapid urease test for presumptive identification of Cryptococcus neoformans.一种用于初步鉴定新型隐球菌的快速脲酶试验。
Mycopathologia. 1996;136(1):21-3. doi: 10.1007/BF00436656.
8
The isolation of Cryptococcus neoformans from pigeon droppings and serotyping of naturally and clinically sourced isolates in China.从鸽粪中分离新型隐球菌以及对中国自然来源和临床来源的分离株进行血清分型。
Mycopathologia. 1993 Oct;124(1):1-5. doi: 10.1007/BF01103049.
9
Emerging fungal pathogens.新出现的真菌病原体
Eur J Clin Microbiol Infect Dis. 1989 Apr;8(4):323-30. doi: 10.1007/BF01963467.
10
Evaluation of a new method for identification of Cryptococcus neoformans which uses serologic tests aided by selected biological tests.一种利用血清学检测并辅以特定生物学检测来鉴定新型隐球菌的新方法的评估。
J Clin Microbiol. 1991 Dec;29(12):2873-6. doi: 10.1128/jcm.29.12.2873-2876.1991.

本文引用的文献

1
Serotyping Cryptococcus neoformans by immunofluorescence.通过免疫荧光对新型隐球菌进行血清分型。
J Clin Microbiol. 1981 Sep;14(3):313-7. doi: 10.1128/jcm.14.3.313-317.1981.
2
Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment.获得性免疫缺陷综合征患者的隐球菌病。诊断特征与治疗结果。
Ann Intern Med. 1986 Feb;104(2):234-40. doi: 10.7326/0003-4819-104-2-234.
3
Rapid selective urease test for presumptive identification of Cryptococcus neoformans.用于新型隐球菌初步鉴定的快速选择性尿素酶试验。
J Clin Microbiol. 1979 Sep;10(3):380-1. doi: 10.1128/jcm.10.3.380-381.1979.
4
Rapid urea broth test for yeasts.酵母的快速尿素肉汤试验
J Clin Microbiol. 1978 Jun;7(6):584-8. doi: 10.1128/jcm.7.6.584-588.1978.

由脲酶阴性新型隐球菌引起的播散性感染。

Disseminated infection caused by urease-negative Cryptococcus neoformans.

作者信息

Ruane P J, Walker L J, George W L

机构信息

Medical Services, West Los Angeles Veterans Administration Medical Center, California 90073.

出版信息

J Clin Microbiol. 1988 Oct;26(10):2224-5. doi: 10.1128/jcm.26.10.2224-2225.1988.

DOI:10.1128/jcm.26.10.2224-2225.1988
PMID:3053768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC266856/
Abstract

We report a case of fungemia and disseminated disease caused by a urease-negative strain of Cryptococcus neoformans in a patient with the acquired immune deficiency syndrome. Except for failure to hydrolyze urea, the microbiological characteristics of the isolate were typical of C. neoformans. Laboratory specialists should be aware of the occurrence of atypical strains of C. neoformans, particularly those recovered from patients with the acquired immune deficiency syndrome.

摘要

我们报告了一例由新型隐球菌尿素酶阴性菌株引起的真菌血症和播散性疾病,该患者患有获得性免疫缺陷综合征。除了不能水解尿素外,该分离株的微生物学特征符合新型隐球菌的典型特征。实验室专业人员应意识到新型隐球菌非典型菌株的出现,尤其是那些从获得性免疫缺陷综合征患者中分离出的菌株。