Smith H R, Scotland S M, Willshaw G A, Wray C, McLaren I M, Cheasty T, Rowe B
Division of Enteric Pathogens, Central Public Health Laboratory, London, UK.
J Gen Microbiol. 1988 Mar;134(3):829-34. doi: 10.1099/00221287-134-3-829.
Vero cytotoxin (VT) production has been studied in 34 Escherichia coli strains isolated from animals with enteric diseases. The strains were tested by DNA hybridization with probes for VT1 and VT2 sequences and also in toxin neutralization experiments with specific antisera. Twenty bovine strains, belonging to nine different O serogroups, produced VT1 or VT2 but not both toxins. In contrast, all 14 porcine strains of four different O serogroups produced VT2 only. Six of these porcine strains, belonging to serogroups O138, O139 and O141, were isolated from cases of oedema disease. In general, the porcine isolates produced toxin at a lower level than the bovine strains.
对从患有肠道疾病的动物中分离出的34株大肠杆菌菌株进行了维罗细胞毒素（VT）产生情况的研究。通过用针对VT1和VT2序列的探针进行DNA杂交以及用特异性抗血清进行毒素中和实验对这些菌株进行检测。20株牛源菌株，分属于9个不同的O血清群，产生VT1或VT2，但不产生两种毒素。相比之下，4个不同O血清群的所有14株猪源菌株仅产生VT2。其中6株猪源菌株，分属于O138、O139和O141血清群，是从水肿病病例中分离出来的。一般来说，猪源分离株产生毒素的水平低于牛源菌株。
