School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, PR China.
School of Chemical Engineering and Energy, Zhengzhou University, No. 100 Science Avenue, Zhengzhou City, Henan Province 450001, PR China.
Biosens Bioelectron. 2018 Dec 15;121:272-280. doi: 10.1016/j.bios.2018.08.061. Epub 2018 Aug 27.
Utilizing biosensors for multiplexed detection can greatly increase analysis throughput and thus, the amount of information obtained in a single assay. The microfluidic chip, a type of micro-total analysis system (µTAS), has provided a necessary platform for portable and high-throughput biosensors. Biosensors and microfluidic chips are powerful individually, and their super combination is very meaningful for analytical especially for biological applications. In this paper, every kind of microfluidic-chip-integrated electronic biosensors including some emerging technologies for simultaneous detection of multiple analytes are reviewed. Different ways to reduce or avoid cross-talking and more efforts to achieve lab on chip multisensors were also introduced to help readers form a general idea of current developments in different angles.
利用生物传感器进行多重检测可以大大提高分析通量，从而在单次测定中获得更多的信息量。微流控芯片作为一种微全分析系统 (µTAS)，为便携式和高通量生物传感器提供了必要的平台。生物传感器和微流控芯片各自都非常强大，它们的超强组合对于分析，特别是生物应用具有非常重要的意义。本文综述了各种集成电子生物传感器的微流控芯片，包括一些用于同时检测多种分析物的新兴技术。还介绍了不同的方法来减少或避免串扰，并努力实现芯片实验室多传感器，以帮助读者从不同角度形成对当前发展的总体认识。
