Zhang Yu, Yan Aijuan, Liu Bingyu, Wan Ying, Zhao Yuchen, Liu Ying, Tan Jiangxiu, Song Lu, Gu Yong, Liu Zhenguo
Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
Front Neurol. 2018 Nov 28;9:960. doi: 10.3389/fneur.2018.00960. eCollection 2018.
Parkinson's disease (PD) patients exhibit deficits in oculomotor behavior, yet the results are inconsistent across studies. In addition, how these results are associated with clinical symptoms is unclear, especially in China. We designed a case-control study in China including 37 PD patients and 39 controls. Clinical manifestations in PD patients were recorded. Oculomotor performance was measured by a video-based eye tracker system. We found that six oculomotor parameters, including fixation stability, saccadic latency, smooth pursuit gain, saccade frequency, viewing range, and saccade frequency during free-viewing context, were significantly different in PD patients and control group. Combining application of these six parameters could improve diagnostic accuracy to over 90%. Moreover, pursuit gain was significantly associated with PD duration, UPDRS III, in PD patients. Saccade latency was significantly associated with PD duration, Berg balance score, RBD score, and Total LEDD in PD patients. PD patients commonly exhibit oculomotor deficits in multiple behavioral contexts, which are associated with both motor and non-motor symptoms. Oculomotor test may provide a valuable tool for the clinical assessment of PD.
帕金森病（PD）患者存在眼球运动行为缺陷，但各研究结果并不一致。此外，这些结果与临床症状之间的关联尚不清楚，在中国尤其如此。我们在中国设计了一项病例对照研究，纳入37例PD患者和39名对照。记录PD患者的临床表现。通过基于视频的眼动追踪系统测量眼球运动表现。我们发现，包括注视稳定性、扫视潜伏期、平稳跟踪增益、扫视频率、视野范围以及自由观看时的扫视频率在内的六个眼球运动参数在PD患者和对照组之间存在显著差异。联合应用这六个参数可将诊断准确率提高到90%以上。此外，在PD患者中，跟踪增益与病程、统一帕金森病评定量表第三部分（UPDRS III）显著相关。扫视潜伏期与PD患者的病程、伯格平衡量表评分、快速眼球运动睡眠行为障碍（RBD）评分以及左旋多巴等效剂量总和（Total LEDD）显著相关。PD患者通常在多种行为情境中表现出眼球运动缺陷，这些缺陷与运动和非运动症状均有关联。眼球运动测试可能为PD的临床评估提供一个有价值的工具。
