Department of Neurology, Qilu Hospital of Shandong University (Qingdao), Qindao, China.
Department of Radiology, Qilu Hospital of Shandong University (Qingdao), Qindao, China.
Neurol Sci. 2021 Jun;42(6):2337-2345. doi: 10.1007/s10072-020-04796-6. Epub 2020 Oct 12.
To detect abnormal eye movements in Parkinson's disease and explore its correlation with clinical characteristics and their value for diagnosis.
We recruited forty-nine Parkinson's disease patients, including 35 early Parkinson's disease patients (Hoehn-Yahr: 1 to 2 stage) and 14 advanced Parkinson's disease patients (Hoehn-Yahr: 3 to 5 stage) and 23 healthy controls. Clinical manifestations in Parkinson's disease patients were recorded. Oculomotor performances including fixation, gaze, saccade in horizontal and vertical direction, and smooth pursuit in horizontal and vertical direction were measured by video-oculography.
We found that five oculomotor parameters, namely square wave jerk frequency, latency of downward saccade, latency of upward saccade, accuracy of upward saccade, and gain of horizontal smooth pursuit were significantly different in Parkinson's disease patients and controls. When combining all these five parameters, we got the diagnostic sensitivity of 78.3% and specificity of 95.2%. More deficits in upward saccade than in other directions were associated with disease duration and progression of Parkinson's disease.
Our primary study suggests that oculomotor examination might serve as an aid in the clinical assessment of Parkinson's disease patients and differentiating between early Parkinson's disease and normal controls.
检测帕金森病患者的异常眼球运动，并探讨其与临床特征的相关性及其对诊断的价值。
我们招募了 49 名帕金森病患者，包括 35 名早期帕金森病患者（Hoehn-Yahr：1 至 2 期）和 14 名晚期帕金森病患者（Hoehn-Yahr：3 至 5 期）和 23 名健康对照者。记录帕金森病患者的临床表现。通过视频眼动描记法测量包括注视、凝视、水平和垂直方向扫视以及水平和垂直方向平滑追踪在内的眼球运动表现。
我们发现，帕金森病患者和对照组之间有五个眼球运动参数存在显著差异，即四方波急动频率、下扫视潜伏期、上扫视潜伏期、上扫视准确性和水平平滑追踪增益。当结合这五个参数时，我们得到了 78.3%的诊断敏感性和 95.2%的特异性。与其他方向相比，上扫视的缺陷更多与疾病持续时间和帕金森病的进展有关。
我们的初步研究表明，眼球运动检查可能有助于帕金森病患者的临床评估，并有助于区分早期帕金森病和正常对照者。
