Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Finland.
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Head Neck. 2019 Oct;41(10):3712-3718. doi: 10.1002/hed.25872. Epub 2019 Jul 22.
Invasion and metastasis are hallmarks of cancer. The concept of tumor budding at tumor-host interface has been documented in many carcinomas. A growing body of evidence indicates that tumor budding is a sign of invasion and early step for metastasis of many epithelial cancers including head and neck squamous cell carcinoma (HNSCC). In addition, recent research has underlined the importance of tumor budding as a promising prognosticator in HNSCC. This review summarizes the findings regarding tumor budding in HNSCC and focuses on the role of tumor budding in invasion and metastasis. Also, we highlight the prognostic significance of tumor budding in HNSCC and its potential for improving clinical decision making in terms of recommending optimal individualized treatment for this patient population.
侵袭和转移是癌症的特征。在许多癌症中，已经有肿瘤在肿瘤-宿主界面处出芽的概念的相关记录。越来越多的证据表明，肿瘤出芽是许多上皮性癌症（包括头颈部鳞状细胞癌[HNSCC]）侵袭和转移的早期步骤。此外，最近的研究强调了肿瘤出芽作为 HNSCC 有前途的预后指标的重要性。这篇综述总结了 HNSCC 中肿瘤出芽的研究结果，并重点介绍了肿瘤出芽在侵袭和转移中的作用。此外，我们还强调了肿瘤出芽在 HNSCC 中的预后意义及其在为该患者人群推荐最佳个体化治疗方面改善临床决策的潜力。
