State key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China; School of pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
State key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China.
Biomed Pharmacother. 2019 Jan;109:1085-1099. doi: 10.1016/j.biopha.2018.10.130. Epub 2018 Nov 6.
Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes and its complications with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a promising molecule for the treatment of these diseases. Finally, we contemplate future development and application prospects of quercetin. Despite the wealth of in animal research results suggesting the anti-diabetic and its complications potential of quercetin, its efficacy in diabetic human subjects is yet to be explored. The problem may become an important direction in the future research.
槲皮素是一种典型的类黄酮，具有多种生化和生理作用，包括抗血小板、雌激素和抗炎作用。本综述主要关注最近十年内关于著名类黄酮槲皮素干预糖尿病及其并发症的发现。在简要介绍槲皮素之后，总结了主要的体外和体内发现，表明槲皮素是治疗这些疾病有前途的分子。最后，我们思考了槲皮素的未来发展和应用前景。尽管大量的动物研究结果表明槲皮素有抗糖尿病及其并发症的潜力，但它在糖尿病患者中的疗效仍有待探索。这个问题可能成为未来研究的一个重要方向。
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