成年哺乳动物大脑中的胰岛素样生长因子-1 系统及其在中枢母体适应中的意义。

The insulin-like growth factor-1 system in the adult mammalian brain and its implications in central maternal adaptation.

机构信息

MTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences and Eötvös Loránd University, Budapest, Hungary.

MTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences and Eötvös Loránd University, Budapest, Hungary; Laboratory of Neuromorphology, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.

出版信息

Front Neuroendocrinol. 2019 Jan;52:181-194. doi: 10.1016/j.yfrne.2018.12.002. Epub 2018 Dec 12.

DOI:10.1016/j.yfrne.2018.12.002

PMID:30552909

Abstract

Our knowledge on the bioavailability and actions of insulin-like growth factor-1 (IGF-1) has markedly expanded in recent years as novel mechanisms were discovered on IGF binding proteins (IGFBPs) and their ability to release IGF-1. The new discoveries allowed a better understanding of the endogenous physiological actions of IGF-1 and also its applicability in therapeutics. The focus of the present review is to summarize novel findings on the neuronal, neuroendocrine and neuroplastic actions of IGF-1 in the adult brain. As most of the new regulatory mechanisms were described in the periphery, their implications on brain IGF system will also be covered. In addition, novel findings on the effects of IGF-1 on lactation and maternal behavior are described. Based on the enormous neuroplastic changes related to the peripartum period, IGF-1 has great but largely unexplored potential in maternal adaptation of the brain, which is highlighted in the present review.

摘要

近年来，随着新的机制在胰岛素样生长因子结合蛋白 (IGFBPs) 及其释放 IGF-1 的能力上被发现，我们对胰岛素样生长因子-1 (IGF-1) 的生物利用度和作用的了解显著增加。这些新发现使我们能够更好地理解 IGF-1 的内源性生理作用及其在治疗中的适用性。本综述的重点是总结 IGF-1 在成年大脑中的神经元、神经内分泌和神经可塑性作用的新发现。由于大多数新的调节机制在周围组织中被描述，因此也将涵盖它们对大脑 IGF 系统的影响。此外，还描述了 IGF-1 对哺乳和母性行为影响的新发现。基于与围产期相关的巨大神经可塑性变化，IGF-1 在大脑的母体适应中具有巨大但在很大程度上尚未被探索的潜力，这在本综述中得到了强调。