Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India.
Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India.
Carbohydr Polym. 2019 Feb 15;206:854-862. doi: 10.1016/j.carbpol.2018.11.033. Epub 2018 Nov 14.
Maturation of bacterial biofilms and their resistance to recurrent antimicrobial agents results in convoluted infectious diseases. In the current study, kappa-Carrageenan (κ-Carrageenan/CRG), was used to formulate CRG-silver nanocomposites through a facile microwave green synthesis approach. CRG-Ag nanoparticles of size 50 ± 10 nm were obtained by using CRG as a reducing and stabilizing agent. CRG-Ag nanoparticles were highly effective against both S. aureus and P. aeruginosa mediated biofilms and acted as a broad spectrum antibacterial agent even after six months. CRG-Ag nanoparticles encapsulated in KCl cross-linked hydrogel also exhibited excellent thermal stability, and antimicrobial potency. All these results depict that CRG-Ag nanocomposites appear as a promising approach to eradicate bacterial biofilms in food packaging and biomedical applications.
细菌生物膜的成熟及其对反复出现的抗菌剂的耐药性导致了复杂的传染病。在本研究中，角叉菜胶（κ-角叉菜胶/CRG）被用于通过简便的微波绿色合成方法来制备 CRG-银纳米复合材料。通过使用 CRG 作为还原剂和稳定剂，获得了尺寸为 50±10nm 的 CRG-Ag 纳米颗粒。CRG-Ag 纳米颗粒对金黄色葡萄球菌和铜绿假单胞菌介导的生物膜具有高度的有效性，并且即使在六个月后也表现出广谱抗菌活性。包封在 KCl 交联水凝胶中的 CRG-Ag 纳米颗粒也表现出优异的热稳定性和抗菌效力。所有这些结果表明，CRG-Ag 纳米复合材料有望成为在食品包装和生物医学应用中根除细菌生物膜的一种有前途的方法。
