Center for Preventive Medicine, Saiseikai Kumamoto Hospital, 5-3-1 Chikami, Minami-ku, Kumamoto, Kumamoto, Japan.
Department of Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Jpn J Radiol. 2019 Mar;37(3):245-254. doi: 10.1007/s11604-018-0800-x. Epub 2018 Dec 15.
To test the tagging efficacy, patient acceptability, and accuracy of computed tomographic colonography (CTC) with a reduced dose of laxative using a novel barium sulfate (BaSO) contrast agent.
CTC followed by optical colonoscopy (OC) was performed on 73 patients with positive results in fecal occult blood tests. They were administrated a BaSO suspension and a magnesium citrate solution for bowel preparation. Patients completed a questionnaire about the acceptability of bowel preparation. Tagging efficacy was estimated using a novel categorization system, which classified all segments into 8 categories. The accuracy of detecting protruded lesions ≥ 6 mm was calculated from the comparison of CTC and OC results, using the latter as a reference standard.
Tagging efficacy was good in 77.3% of colonic segments where residue was observed. The acceptability of bowel preparation for CTC was significantly higher than that for OC. The sensitivity, specificity, and positive and negative predictive values were 0.778, 0.945, 0.824, and 0.929, respectively. All lesions ≥ 7 mm were successfully detected by CTC.
CTC with a reduced dose of laxative using a novel BaSO contrast agent has a favorable tagging efficacy, patient acceptability, and accuracy.
使用新型硫酸钡（BaSO）造影剂，测试低剂量泻药下计算机断层结肠成像（CTC）的标记效果、患者接受度和准确性。
对粪便潜血试验阳性的 73 例患者进行 CTC 检查，随后进行光学结肠镜检查（OC）。他们接受了 BaSO 混悬液和柠檬酸镁溶液进行肠道准备。患者完成了一份关于肠道准备接受度的调查问卷。标记效果使用一种新的分类系统进行评估，该系统将所有节段分为 8 个类别。通过将 CTC 结果与 OC 结果进行比较，计算出检测突出病变≥6mm的准确性，后者作为参考标准。
在观察到残留的 77.3%结肠段中，标记效果良好。CTC 肠道准备的接受度明显高于 OC。灵敏度、特异性、阳性预测值和阴性预测值分别为 0.778、0.945、0.824 和 0.929。所有≥7mm的病变均被 CTC 成功检出。
使用新型 BaSO 造影剂的低剂量泻药 CTC 具有良好的标记效果、患者接受度和准确性。
