From Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Neurology. 2020 Apr 7;94(14):e1539-e1547. doi: 10.1212/WNL.0000000000009214. Epub 2020 Mar 11.
To determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire.
In this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual Impairment in Parkinson's Disease Questionnaire (VIPD-Q). The VIPD-Q addressed 4 domains according to structures: (1) ocular surface; (2) intraocular; (3) oculomotor; and (4) optic nerve. The questionnaire also assessed the effect of ophthalmologic symptoms on daily activities.
One or more ophthalmologic symptoms were reported by 82% (95% confidence interval [CI], 80-85) of patients, compared with 48% (95% CI, 42-54) of controls ( < 0.001). Patients with PD experienced more ophthalmologic symptoms across all domains than controls ( < 0.001), as reflected by a higher VIPD-Q total score among patients (median 10 [interquartile range (IQR) 13]) than controls (median 2 [IQR 5]; < 0.001). Ophthalmologic symptoms interfered with daily activities in 68% (95% CI, 65-71) of patients, compared with 35% (95% CI, 29-41) of controls ( < 0.001).
Patients with PD have a higher prevalence of ophthalmologic symptoms than controls. Moreover, these frequently interfere with daily activities. A screening questionnaire such as the VIPD-Q may help with identifying ophthalmologic symptoms in PD, thereby enabling more timely treatment.
使用标准化问卷，确定帕金森病（PD）患者与对照组相比，眼部症状的患病率和临床影响。
在这项观察性、横断面、多中心研究中，848 名 PD 患者和 250 名健康对照者完成了帕金森病眼部损害问卷（VIPD-Q）。该问卷根据结构分为 4 个领域：（1）眼表面；（2）眼内；（3）眼运动；（4）视神经。问卷还评估了眼部症状对日常活动的影响。
82%（95%置信区间[CI]，80-85）的患者报告存在 1 种或多种眼部症状，而对照组为 48%（95% CI，42-54）（<0.001）。与对照组相比，PD 患者在所有领域都经历了更多的眼部症状（<0.001），这反映在患者的 VIPD-Q 总分更高（中位数 10[四分位距[IQR] 13]）而对照组中位数为 2[IQR 5]；<0.001）。68%（95% CI，65-71）的患者眼部症状干扰了日常活动，而对照组为 35%（95% CI，29-41）（<0.001）。
PD 患者眼部症状的患病率高于对照组。此外，这些症状常常会干扰日常活动。VIPD-Q 等筛查问卷有助于识别 PD 中的眼部症状，从而能够及时进行治疗。
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