使用钪催化剂对受阻烯烃与 N,N-二甲基苯胺的氢氨基烷基化反应。
Hydroaminoalkylation of sterically hindered alkenes with N,N-dimethyl anilines using a scandium catalyst.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
出版信息
Org Biomol Chem. 2019 Feb 13;17(7):2013-2019. doi: 10.1039/c8ob02657b.
An atom- and step-economical C(sp3)-H addition of N,N-dimethyl anilines to various sterically demanding 1,1- and 1,2-disubstituted alkenes has been achieved by using a simple β-diketiminato ligand supported scandium dialkyl complex in combination with a borate compound. The corresponding C(sp3)-C(sp3) bond forming reaction occurs with excellent regioselectivities to give a variety of tertiary aromatic amines.
通过使用简单的β-二酮亚胺配体负载的钪二烷基配合物与硼酸化合物的组合，实现了 N,N-二甲基苯胺与各种空间位阻较大的 1,1-和 1,2-取代烯烃的原子经济性和步骤经济性的 C(sp3)-H 添加。相应的 C(sp3)-C(sp3)键形成反应具有优异的区域选择性，生成各种叔芳基胺。
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