Buchanan J M, Baldasera J, Poole P H, Halshaw J, Dallard J K
Sunderland District General Hospital.
Ann R Coll Surg Engl. 1988 Sep;70(5):332-5.
The pain relief provided by regular intramuscular diclofenac and on demand intramuscular papaveretum was compared over a 48 h postoperative period in 114 patients undergoing total hip replacement. The study was of a randomised, single-blind, between-group design. Patients were assessed by a surgeon, physiotherapist and nursing staff. Diclofenac was more effective than papaveretum in pain control (P less than 0.001), wound tenderness (P less than 0.01), awareness (P less than 0.001) and mobilisation (P less than 0.01). Wound drainage (P greater than 0.05) and wound oedema (P greater than 0.05) were not significantly different in the two treatments. Gastrointestinal complications were encountered in both groups; two patients on diclofenac had to be withdrawn because of them. The use of diclofenac given as a postoperative analgesic is rewarding, particularly in patients undergoing musculoskeletal procedures. Patients will be more comfortable and will mobilise better during their whole postoperative course.
在114例行全髋关节置换术的患者中,比较了术后48小时内常规肌肉注射双氯芬酸和按需肌肉注射罂粟碱的止痛效果。该研究采用随机、单盲、组间设计。由外科医生、物理治疗师和护理人员对患者进行评估。在疼痛控制(P<0.001)、伤口压痛(P<0.01)、清醒程度(P<0.001)和活动能力(P<0.01)方面,双氯芬酸比罂粟碱更有效。两种治疗方法的伤口引流(P>0.05)和伤口水肿(P>0.05)无显著差异。两组均出现胃肠道并发症;两名使用双氯芬酸的患者因此不得不退出研究。术后使用双氯芬酸作为镇痛药是值得的,尤其是在接受肌肉骨骼手术的患者中。患者在整个术后过程中会感觉更舒适,活动能力也会更好。