1 Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.
2 Farm Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Microb Drug Resist. 2019 May;25(4):603-610. doi: 10.1089/mdr.2018.0277. Epub 2018 Dec 18.
The aim of this trial was to evaluate the effectiveness of injectable antibiotics of one- or two-dose administration on recovery of acute App ()-infected pigs. Ninety pigs with moderate general clinical score (GCS) of a commercial farm, suffering from acute App infection, were divided in two groups: (a) T1: one administration of gamithromycin injectable solution and (b) T2: two administrations of florfenicol injectable solution. Morbidity/mortality, clinical scores (clinical appearance score index-CAS, clinical respiratory score-CRS, clinical cough score index [CCS], general respiratory clinical score-GCRS, and general clinical score-GCS), body temperature score (BTS), and posttreatment interval were recorded. The carcass weight and lung scoring were estimated, based on slaughterhouse pleurisy evaluation system score, lung lobes score, and pneumonia area. The results of this study indicated that the tested antibiotics are efficacious for the recovery of acute App-affected pigs. Quicker improvement of BTS in sick pigs (at day 1 and 2) and quicker recovery of clinical signs, based on the improvement of clinical parameters (CAS, CCS, GCRS, GCS on day 2 and 3, and CRS on day 2), were noticed in T1 group. In conclusion, the use of tested antibiotics in acute App-affected pigs is an effective strategy for the control of an acute outbreak.
本试验旨在评估单剂量和双剂量注射用抗生素对急性 APP(传染性胸膜肺炎放线杆菌)感染猪康复的效果。从一家商业农场中,选择 90 头具有中度一般临床评分(GCS)、患有急性 APP 感染的猪,分为两组:(a)T1:注射用加米霉素溶液一次给药;(b)T2:注射用氟苯尼考溶液两次给药。记录发病率/死亡率、临床评分(临床外观评分指数-CAS、临床呼吸评分-CRS、临床咳嗽评分指数 [CCS]、一般呼吸临床评分-GCRS 和一般临床评分-GCS)、体温评分(BTS)和治疗后间隔。基于屠宰场胸膜炎评估系统评分、肺叶评分和肺炎面积,估计胴体重量和肺评分。本研究结果表明,所测试的抗生素对急性 APP 感染猪的康复是有效的。T1 组中,患病猪的 BTS 在第 1 天和第 2 天更快地改善,临床参数(CAS、CCS、GCRS、GCS 在第 2 天和第 3 天,以及 CRS 在第 2 天)更快地恢复,临床症状更快地恢复。总之,在急性 APP 感染猪中使用测试抗生素是控制急性暴发的有效策略。