Inayat Faisal, Zafar Fahad, Riaz Iqra, Younus Fariha, Baig Asad S, Imran Zahid
Internal Medicine, Allama Iqbal Medical College, Lahore, PAK.
Internal Medicine, King Edward Medical University, Lahore, PAK.
Cureus. 2018 Oct 17;10(10):e3461. doi: 10.7759/cureus.3461.
Hypertriglyceridemic pancreatitis (HTGP) is an uncommon but well-established clinical entity. Although the initial clinical features are similar to pancreatitis due to other etiologies, the severity of the disease and the risk of complications are higher in these patients. Prompt diagnosis and appropriate treatment are crucial in patients with hypertriglyceridemia-induced pancreatitis to avoid life-threatening complications. The initial conservative treatment is applied followed by additional specific therapies tailored to decrease serum triglyceride levels. This includes plasmapheresis, insulin, heparin infusion, and hemofiltration. After the acute episode, lifestyle modifications along with hypolipidemic medications should be initiated to prevent further events. Currently, there is paucity of the medical literature directly comparing different treatment modalities. This article illustrates the use of insulin therapy for HTGP as a feasible therapeutic choice. Randomized controlled trials are warranted to outline a generalized and efficient treatment for this serious disorder.
高甘油三酯血症性胰腺炎（HTGP）是一种罕见但已被充分认识的临床实体。尽管其初始临床特征与其他病因引起的胰腺炎相似，但这些患者的疾病严重程度和并发症风险更高。对于高甘油三酯血症诱发的胰腺炎患者，及时诊断和适当治疗对于避免危及生命的并发症至关重要。首先采用保守治疗，随后根据具体情况采用特定疗法以降低血清甘油三酯水平。这包括血浆置换、胰岛素、肝素输注和血液滤过。急性发作后，应进行生活方式调整并使用降血脂药物以预防进一步发作。目前，直接比较不同治疗方式的医学文献较少。本文阐述了将胰岛素治疗用于HTGP作为一种可行的治疗选择。有必要进行随机对照试验以勾勒出针对这种严重疾病的通用且有效的治疗方法。
