Chen Yiren, Deb Sayantan, Jabarkheel Rashad, Pham Lan, Patel Mahesh, Singh Harminder
Neurosurgery, Stanford University Medical Center, Stanford, USA.
Neurosurgery, Stanford University School of Medicine, Stanford, USA.
Cureus. 2018 Oct 17;10(10):e3462. doi: 10.7759/cureus.3462.
Background Pedicle screw fixation is currently the mainstay technique for lumbar spinal fusion; however, more minimally invasive techniques are available such as cortical screw fixation. Numerous studies have proven biomechanical equivalence or superiority for cortical screws but few studies have examined clinical outcomes in patients. Our study aims to examine functional outcomes, as well as fusion rates, in patients who underwent pedicle screw fixation using a cortical trajectory. Methods We retrospectively reviewed prospectively collected functional outcomes data on 10 patients with a degenerative lumbar disease who underwent cortical screw placement by the senior author. Oswestry Disability Index (ODI) and Roland Morris (RM) scoring were calculated preoperatively, at six to 12 weeks and at six to eight months. The Kruskal-Wallis test and Dunn's multiple comparison were used to analyze differences in scores over time. Results We found that over time, cortical screw fixation resulted in a mean decrease of 27 from the baseline ODI at six to eight months (p = 0.014). Additionally, six out of seven (86%) patients who had at least 12 months of radiographic follow-up showed fusion. Conclusions Cortical screw fixation showed a decrease of 27 from the baseline ODI at six to eight months, which is comparable to changes from the baseline ODI reported in three, recent, large clinical trials examining functional outcomes following traditional pedicle screw fixation.
背景 椎弓根螺钉固定术目前是腰椎融合的主要技术;然而,现在有更多的微创技术可供选择,比如皮质骨螺钉固定术。众多研究已证实皮质骨螺钉在生物力学方面相当或更具优势,但很少有研究考察其在患者中的临床疗效。我们的研究旨在考察采用皮质骨入路行椎弓根螺钉固定术患者的功能结局以及融合率。方法 我们回顾性分析了由资深作者为10例退行性腰椎疾病患者行皮质骨螺钉置入术的前瞻性收集的功能结局数据。术前、术后6至12周以及6至8个月时计算Oswestry功能障碍指数(ODI)和罗兰·莫里斯(RM)评分。采用Kruskal-Wallis检验和邓恩多重比较分析不同时间点评分的差异。结果 我们发现,随着时间推移,皮质骨螺钉固定术在术后6至8个月时使ODI较基线水平平均降低了27分(p = 0.014)。此外,在至少有12个月影像学随访的7例患者中,有6例(86%)显示融合。结论 皮质骨螺钉固定术在术后6至8个月时使ODI较基线水平降低了27分,这与最近三项关于传统椎弓根螺钉固定术后功能结局的大型临床试验所报告的ODI较基线水平的变化相当。