Lin Tzu-Wei, Tsai Sheng-Feng, Kuo Yu-Min
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta, Georgia, USA.
Brain Plast. 2018 Dec 12;4(1):95-110. doi: 10.3233/BPL-180073.
Accumulating evidence indicates that exercise can improve learning and memory as well as attenuate neurodegeneration, including Alzheimer's disease (AD). In addition to improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates systems like angiogenesis and glial activation that are known to support neuroplasticity. Moreover, exercise helps to maintain a cerebral microenvironment that facilitates synaptic plasticity by enhancing the clearance of A, one of the main culprits of AD pathogenesis. The purpose of this review is to highlight the positive impacts of exercise on promoting neuroplasticity. Possible mechanisms involved in exercise-modulated neuroplasticity are also discussed. Undoubtedly, more studies are needed to design an optimal personalized exercise protocol for enhancing brain function.
越来越多的证据表明，运动可以改善学习和记忆，以及减轻神经退行性变，包括阿尔茨海默病（AD）。运动除了通过改变不同脑区的突触结构和功能来改善神经可塑性外，还调节诸如血管生成和胶质细胞激活等已知支持神经可塑性的系统。此外，运动有助于维持一个脑微环境，通过增强AD发病机制的主要元凶之一——Aβ的清除来促进突触可塑性。本综述的目的是强调运动对促进神经可塑性的积极影响。还讨论了运动调节神经可塑性所涉及的可能机制。毫无疑问，需要更多的研究来设计一个最佳的个性化运动方案以增强脑功能。
