体育锻炼增强神经可塑性并延缓阿尔茨海默病。
Physical Exercise Enhances Neuroplasticity and Delays Alzheimer's Disease.
作者信息
Lin Tzu-Wei, Tsai Sheng-Feng, Kuo Yu-Min
机构信息
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta, Georgia, USA.
出版信息
Brain Plast. 2018 Dec 12;4(1):95-110. doi: 10.3233/BPL-180073.
Abstract
Accumulating evidence indicates that exercise can improve learning and memory as well as attenuate neurodegeneration, including Alzheimer's disease (AD). In addition to improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates systems like angiogenesis and glial activation that are known to support neuroplasticity. Moreover, exercise helps to maintain a cerebral microenvironment that facilitates synaptic plasticity by enhancing the clearance of A, one of the main culprits of AD pathogenesis. The purpose of this review is to highlight the positive impacts of exercise on promoting neuroplasticity. Possible mechanisms involved in exercise-modulated neuroplasticity are also discussed. Undoubtedly, more studies are needed to design an optimal personalized exercise protocol for enhancing brain function.
摘要
越来越多的证据表明，运动可以改善学习和记忆，以及减轻神经退行性变，包括阿尔茨海默病（AD）。运动除了通过改变不同脑区的突触结构和功能来改善神经可塑性外，还调节诸如血管生成和胶质细胞激活等已知支持神经可塑性的系统。此外，运动有助于维持一个脑微环境，通过增强AD发病机制的主要元凶之一——Aβ的清除来促进突触可塑性。本综述的目的是强调运动对促进神经可塑性的积极影响。还讨论了运动调节神经可塑性所涉及的可能机制。毫无疑问，需要更多的研究来设计一个最佳的个性化运动方案以增强脑功能。
相似文献
1
Physical Exercise Enhances Neuroplasticity and Delays Alzheimer's Disease.
Brain Plast. 2018 Dec 12;4(1):95-110. doi: 10.3233/BPL-180073.
2
Physical Exercise Inhibits Inflammation and Microglial Activation.
Cells. 2019 Jul 9;8(7):691. doi: 10.3390/cells8070691.
3
Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice.
Neurobiol Learn Mem. 2015 Feb;118:189-97. doi: 10.1016/j.nlm.2014.12.005. Epub 2014 Dec 24.
4
A review of the application of exercise intervention on improving cognition in patients with Alzheimer's disease: mechanisms and clinical studies.
Rev Neurosci. 2024 Jul 22;36(1):1-25. doi: 10.1515/revneuro-2024-0046. Print 2025 Jan 29.
5
Beneficial effects of physical exercise on neuroplasticity and cognition.
Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2243-57. doi: 10.1016/j.neubiorev.2013.04.005. Epub 2013 Apr 25.
6
Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity.
Front Mol Neurosci. 2020 Aug 21;13:151. doi: 10.3389/fnmol.2020.00151. eCollection 2020.
7
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease.
Neurobiol Dis. 2013 Sep;57:47-55. doi: 10.1016/j.nbd.2012.06.011. Epub 2012 Jun 30.
8
Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease.
Neural Regen Res. 2024 Mar;19(3):619-628. doi: 10.4103/1673-5374.380874.
9
Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology.
J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8.
10
Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.
Eur J Med Chem. 2019 May 1;169:185-199. doi: 10.1016/j.ejmech.2019.03.009. Epub 2019 Mar 8.
引用本文的文献
1
Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson's disease.
Front Aging Neurosci. 2025 Aug 26;17:1580029. doi: 10.3389/fnagi.2025.1580029. eCollection 2025.
2
Mechanisms of IGF1R signaling in type 2 diabetes-related neurodegeneration and therapeutic implications of exercise.
Eur J Med Res. 2025 Aug 30;30(1):825. doi: 10.1186/s40001-025-03087-0.
3
Inflammation and depression: an evolutionary framework for the role of physical activity and exercise.
Front Psychol. 2025 May 29;16:1554062. doi: 10.3389/fpsyg.2025.1554062. eCollection 2025.
4
Signs of Alzheimer's Disease: Tied to Aging.
Int J Mol Sci. 2025 May 22;26(11):4974. doi: 10.3390/ijms26114974.
5
Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain-muscle-liver axis to slow down aging and neurodegeneration: a narrative review.
Eur J Med Res. 2025 Jun 12;30(1):475. doi: 10.1186/s40001-025-02751-9.
6
Gut-brain-immune axis implications for mental health and disease.
Mol Cell Biochem. 2025 Jun 12. doi: 10.1007/s11010-025-05325-9.
7
Environmental adversity, endoplasmic reticulum stress, and neurogenesis.
Neurotoxicology. 2025 Jul;109:32-45. doi: 10.1016/j.neuro.2025.05.010. Epub 2025 May 31.
8
Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases.
Antioxidants (Basel). 2025 May 7;14(5):554. doi: 10.3390/antiox14050554.
9
Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review.
Front Immunol. 2025 Apr 30;16:1576283. doi: 10.3389/fimmu.2025.1576283. eCollection 2025.
10
Associations of Metabolic Syndrome and Insulin Resistance With Attenuated Executive Function Post-Preeclampsia: A Nested Case-Control Study.
BJOG. 2025 Aug;132(9):1269-1277. doi: 10.1111/1471-0528.18186. Epub 2025 Apr 29.
本文引用的文献
1
Long-Term Moderate Exercise Rescues Age-Related Decline in Hippocampal Neuronal Complexity and Memory.
Gerontology. 2018;64(6):551-561. doi: 10.1159/000488589. Epub 2018 May 7.
2
Proinflammatory cytokines correlate with early exercise attenuating anxiety-like behavior after cerebral ischemia.
Brain Behav. 2017 Oct 18;7(11):e00854. doi: 10.1002/brb3.854. eCollection 2017 Nov.
3
Running wheel exercise reduces renewal of extinguished instrumental behavior and alters medial prefrontal cortex neurons in adolescent, but not adult, rats.
Behav Neurosci. 2017 Dec;131(6):460-469. doi: 10.1037/bne0000218. Epub 2017 Oct 30.
4
Modulation of mitochondrial dynamics by treadmill training to improve gait and mitochondrial deficiency in a rat model of Parkinson's disease.
Life Sci. 2017 Dec 15;191:236-244. doi: 10.1016/j.lfs.2017.10.003. Epub 2017 Oct 3.
5
Exercise pattern and distance differentially affect hippocampal and cerebellar expression of FLK-1 and FLT-1 receptors in astrocytes and blood vessels.
Behav Brain Res. 2018 Jan 30;337:8-16. doi: 10.1016/j.bbr.2017.09.037. Epub 2017 Sep 25.
6
The Effects of Resistance Exercise Training on Anxiety: A Meta-Analysis and Meta-Regression Analysis of Randomized Controlled Trials.
Sports Med. 2017 Dec;47(12):2521-2532. doi: 10.1007/s40279-017-0769-0.
7
Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults.
Sci Rep. 2017 Jul 11;7(1):5140. doi: 10.1038/s41598-017-04850-y.
8
Exercise makes your brain bigger: skeletal muscle VEGF and hippocampal neurogenesis.
J Physiol. 2017 Sep 1;595(17):5721-5722. doi: 10.1113/JP274658. Epub 2017 Jul 26.
9
The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology.
Int J Mol Sci. 2017 Jun 20;18(6):1319. doi: 10.3390/ijms18061319.
10
Skeletal myofiber vascular endothelial growth factor is required for the exercise training-induced increase in dentate gyrus neuronal precursor cells.
J Physiol. 2017 Sep 1;595(17):5931-5943. doi: 10.1113/JP273994. Epub 2017 Jun 28.
Zotero 插件