Endo Nozomi, Ujita Waka, Fujiwara Masaya, Miyauchi Hideaki, Mishima Hiroyuki, Makino Yusuke, Hashimoto Lisa, Oyama Hiroshi, Makinodan Manabu, Nishi Mayumi, Tohyama Chiharu, Kakeyama Masaki
1Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, 113-0033 Japan.
2Laboratory for Systems Neurosciences and Preventive Medicine, Faculty of Human Sciences, Waseda University, Tokorozawa, 359-1192 Japan.
Commun Biol. 2018 Dec 11;1:225. doi: 10.1038/s42003-018-0213-5. eCollection 2018.
Social relationships are a key determinant of social behaviour, and disruption of social behaviour is a major symptom of several psychiatric disorders. However, few studies have analysed social relationships among multiple individuals in a group or how social relationships within a group influence the behaviour of members with impaired socialisation. Here, we developed a video-analysis-based system, the Multiple-Animal Positioning System (MAPS), to automatically and separately analyse the social behaviour of multiple individuals in group housing. Using MAPS, we show that social isolation of male mice during adolescence leads to impaired social proximity in adulthood. The phenotype of these socially isolated mice was partially rescued by cohabitation with group-housed (socially-reared) mice, indicating that both individual behavioural traits and those of cagemates influence social proximity. Furthermore, we demonstrate that low reactive behaviour of other cagemates also influence individual social proximity in male mice.
社会关系是社会行为的关键决定因素，而社会行为的破坏是几种精神疾病的主要症状。然而，很少有研究分析群体中多个个体之间的社会关系，或者群体内部的社会关系如何影响社交能力受损成员的行为。在这里，我们开发了一种基于视频分析的系统，即多动物定位系统（MAPS），用于自动且分别地分析群居环境中多个个体的社会行为。使用MAPS，我们发现青春期雄性小鼠的社会隔离会导致成年后社会亲近能力受损。这些社会隔离小鼠的表型通过与群居（社会饲养）小鼠同居而得到部分挽救，这表明个体行为特征和笼伴的行为特征都会影响社会亲近能力。此外，我们证明其他笼伴的低反应性行为也会影响雄性小鼠的个体社会亲近能力。
