Sporrong T, Hellgren M, Samsioe G, Mattsson L A
Department of Obstetrics and Gynecology, East Hospital, University of Göteborg, Sweden.
Br J Obstet Gynaecol. 1988 Oct;95(10):1042-8. doi: 10.1111/j.1471-0528.1988.tb06511.x.
Sixty women with climacteric complaints who had not menstruated for at least 1 year were randomly allocated to receive one of four hormonal replacement regimens. All four formulations were administered daily and continuously and each contained 2 mg of micronized oestradiol-17 beta in combination with either norethisterone acetate 1 mg (group A) or 0.5 mg (group B) or megestrol acetate 5 mg (group C) or 2.5 mg (group D). The clinical efficacy was the same although the alleviation of vasomotor symptoms was somewhat slower in those women receiving preparation A. The endometrium was atrophied in nearly all biopsies. Irregular uterine bleeding was almost entirely confined to the earlier phase of the study and was substantially less with the formulation containing 1 mg norethisterone acetate. It is concluded that a continuous oestradiol-progestogen combination can be used for long-term treatment of climacteric complaints in postmenopausal women and that after 4 months the clinical efficacy is the same irrespective of the type and dose of progestogen administered.
60名有更年期症状且至少1年未行经的女性被随机分配接受四种激素替代方案中的一种。所有四种制剂均每日持续给药，每种制剂均含有2mg微粒化雌二醇-17β，并分别与1mg醋酸炔诺酮（A组）、0.5mg醋酸炔诺酮（B组）、5mg醋酸甲地孕酮（C组）或2.5mg醋酸甲地孕酮（D组）联合使用。尽管接受制剂A的女性血管舒缩症状的缓解稍慢，但临床疗效相同。几乎所有活检的子宫内膜均萎缩。不规则子宫出血几乎完全局限于研究的早期阶段，且含1mg醋酸炔诺酮的制剂所致出血明显较少。结论是，连续雌二醇-孕激素联合用药可用于绝经后女性更年期症状的长期治疗，且4个月后，无论所用孕激素的类型和剂量如何，临床疗效相同。
