Hellberg D, Nilsson S
Maturitas. 1984 Apr;5(4):233-43. doi: 10.1016/0378-5122(84)90016-1.
This study was undertaken to evaluate the effects of oestriol in combination with oestradiol in the treatment of women with climacteric complaints. Forty-three post-menopausal women were randomly allocated to two groups on a double-blind basis. Over a 28-day cycle 23 of the women were treated sequentially for 12 days with 1 tablet containing 17 beta-oestradiol 2 mg plus oestriol 1 mg, then for 10 days with 1 tablet containing the same oestrogens plus norethisterone acetate 1 mg, thereafter for 6 days with 1 tablet containing 17 beta-oestradiol 1 mg plus oestriol 0.5 mg. The other 20 women received the same treatment but without the oestriol. No clinical, laboratory or histological differences were seen between the two groups. Both treatments were found to be equally effective in alleviating climacteric symptoms, with few side effects. It may be stated in conclusion that, on the basis of routine clinical and laboratory parameters no differences were found between the two preparations.
本研究旨在评估雌三醇与雌二醇联合用药对患有更年期症状女性的治疗效果。43名绝经后女性被双盲随机分为两组。在一个28天的周期内，23名女性先连续12天服用1片含17β-雌二醇2毫克加雌三醇1毫克的药片，然后连续10天服用1片含相同雌激素加醋酸炔诺酮1毫克的药片，之后连续6天服用1片含17β-雌二醇1毫克加雌三醇0.5毫克的药片。另外20名女性接受相同治疗，但不含雌三醇。两组之间未观察到临床、实验室或组织学差异。两种治疗方法在缓解更年期症状方面同样有效，且副作用较少。综上所述，根据常规临床和实验室参数，两种制剂之间未发现差异。
